Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Department of Algology, Ankara Training and Research Hospital, Ankara, Turkey.
Afr Health Sci. 2023 Sep;23(3):99-108. doi: 10.4314/ahs.v23i3.13.
In this study, we aimed to determine the potential effects of metabolic syndrome (MetS) and its components on bone mineral density (BMD) in the lumbar spine and femoral neck in postmenopausal Turkish women.
193 postmenopausal women were included in this study. Anthropometric measurements, biochemical blood tests, and T-scores of BMD in the lumbar spine (L1-L4) and femoral neck were recorded. The participants were divided into two groups according to the bone mineral density (BMD) results as osteoporosis group (Group 1, n=109) who had a T-score>-2.5 at the spine or/and femoral neck, and the control group (Group 2, n=84) who had T-score>-2.5 at the spine or/and femoral neck. MetS and its components were screened using the criteria of the Adult Treatment Panel III (ATP III) and National Cholesterol Education Program (NCEP). The effects of the MetS components on T-scores of BMD at the femoral neck and lumbar spine were evaluated by partial correlation test and multiple regression analysis.
MetS was detected in 58 (30.1%) participants. The prevalence of MetS was significantly higher in Group 2 compared to Group 1 (39.3% vs 22.9%, p=0,014). Among the MetS components, especially abdominal obesity showed a significant positive correlation with T-scores of BMD at the femoral neck and spine. A weak but significant correlation was also observed with systolic and diastolic blood pressure, serum triglyceride levels, and fasting blood glucose (FBG). Multiple regression analysis revealed an association between waist circumference and BMD at both femoral neck and spine, and also between serum triglycerides, systolic and diastolic blood pressure, and spine BMD.
Our findings support that MetS is associated with increased BMD at the femoral neck and spine in postmenopausal women. A significant positive association was observed among the MetS components, especially with abdominal obesity, and also a weak positive association with serum triglycerides, and systolic and diastolic blood pressure.
本研究旨在探讨代谢综合征（MetS）及其各组分对绝经后土耳其女性腰椎和股骨颈骨密度（BMD）的潜在影响。
纳入 193 例绝经后女性，记录其人体测量学指标、生化血液检查及腰椎（L1-L4）和股骨颈 BMD 的 T 评分。根据 BMD 结果将患者分为骨质疏松组（T 评分＜-2.5 于脊柱或/和股骨颈，n=109）和对照组（T 评分≥-2.5 于脊柱或/和股骨颈，n=84）。采用成人治疗小组 III（ATP III）和国家胆固醇教育计划（NCEP）的标准筛选 MetS 及其各组分。采用偏相关分析和多元回归分析评估 MetS 各组分对股骨颈和腰椎 BMD T 评分的影响。
58 例（30.1%）患者检出 MetS。与对照组相比，骨质疏松组中 MetS 的检出率显著更高（39.3%比 22.9%，p=0.014）。MetS 各组分中，尤其腹型肥胖与股骨颈和脊柱 BMD T 评分呈显著正相关，与收缩压、舒张压、血清甘油三酯水平和空腹血糖（FBG）也呈弱但显著的正相关。多元回归分析显示，腰围与股骨颈和脊柱的 BMD 均相关，血清甘油三酯、收缩压和舒张压也与脊柱 BMD 相关。
本研究结果支持绝经后女性 MetS 与股骨颈和脊柱 BMD 增加相关。MetS 各组分中，尤其腹型肥胖与 BMD 呈显著正相关，与血清甘油三酯和收缩压、舒张压也呈弱正相关。
