Department of Internal Medicine, Cardiology, Heart Surgery and Immunological Sciences, University Federico II of Naples, Italy.
Am J Cardiol. 2011 Oct 15;108(8):1171-6. doi: 10.1016/j.amjcard.2011.06.022. Epub 2011 Jul 26.
Several studies have investigated the frequency of familial dilated cardiomyopathy (FDC). However, no systematic review and meta-analysis on this topic are available. Therefore, using the PubMed, MEDLINE, Cochrane, and the ISI Web of Science databases, relevant reports published through December 2010 were identified. For the summation of prevalence findings, prevalence point estimates and 95% confidence intervals were computed using the logit transformation formula. An aggregate estimate of clinically confirmed FDC of 23% (95% confidence interval 0.17 to 0.31) was found. However, the prevalence rates reported across these studies varied widely, ranging from 2% to 65%, and the analysis showed very high heterogeneity (Q = 295, p <0.001, I(2) = 93%). Meta-regression analysis between logit event rate and year of publication explained 23% of between-study variance (p <0.05). Cumulative meta-analysis confirmed the influence of year of publication on the reported prevalence of FDC among the different studies. However, most of the observed heterogeneity may be explained by the fact that the various studies used different preselected criteria for the diagnosis of FDC. In conclusion, data obtained from trials performed using standardized criteria are needed to better define the true prevalence of FDC.
已有几项研究调查了家族性扩张型心肌病（FDC）的频率。然而，目前尚无关于该主题的系统评价和荟萃分析。因此，我们使用 PubMed、MEDLINE、Cochrane 和 ISI Web of Science 数据库，检索了截至 2010 年 12 月发表的相关报告。对于患病率发现的汇总，使用对数转换公式计算患病率点估计值和 95%置信区间。发现临床确诊的 FDC 的总体估计值为 23%（95%置信区间为 0.17 至 0.31）。然而，这些研究报告的患病率差异很大，范围从 2%至 65%，分析显示异质性非常高（Q=295，p<0.001，I²=93%）。对数事件率与出版年份之间的元回归分析解释了研究间变异的 23%（p<0.05）。累积荟萃分析证实了出版年份对不同研究中报告的 FDC 患病率的影响。然而，大多数观察到的异质性可能归因于这样一个事实，即各种研究使用不同的预先选择的标准来诊断 FDC。总之，需要使用标准化标准进行的试验获得的数据来更好地定义 FDC 的真实患病率。
