Dhom G
Tumorcenter, University of Saarland, Homburg/Saar, FRG.
Pathol Res Pract. 1990 Feb;186(1):28-36. doi: 10.1016/S0344-0338(11)81009-5.
Over 90% of malignant epithelial tumors of the prostate are common carcinomas. Uncommon or rare prostate carcinomas can histogenetically be related to 4 epithelial types of the prostate: the secretory epithelium, the basal cells, the endocrine cells and the transitional epithelium. The rare, purely mucinous carcinoma and the ductal papillary carcinoma belong to the type of secretory epithelium. The latter is rarely seen in the large central prostatic ducts, it develops more frequently in peripheral ducts and is combined with common prostate carcinoma. The so-called endometrioid carcinomas of the utriculus described in the literature are probably ductal prostate carcinomas. To date no carcinoma has been found in the utriculus. The adenoid cystic carcinoma of the prostate is a basal cell tumor with preponderantly good prognosis. Endocrine cells are disseminated in most common prostate carcinomas. Thereby mixed forms showing both portions of a common adenocarcinoma and of a carcinoid may occur. Pure carcinoids of prostate are rare findings. The small cell carcinoma of the prostate is the highly malignant variant of the endocrine cell type. Immunohistochemically, a multitude of proteohormones are demonstrable in endocrine tumor cells. The ectopic ACTH production with Cushing's syndrome is of particular clinical significance.
超过90%的前列腺恶性上皮性肿瘤是常见的癌。不常见或罕见的前列腺癌在组织发生学上可与前列腺的4种上皮类型相关：分泌上皮、基底细胞、内分泌细胞和移行上皮。罕见的纯黏液癌和导管乳头状癌属于分泌上皮类型。后者在前列腺中央大导管中很少见，在外周导管中更常见，并常与常见的前列腺癌合并。文献中描述的所谓前列腺囊子宫内膜样癌可能是导管前列腺癌。迄今为止，在前列腺囊中尚未发现癌。前列腺腺样囊性癌是一种基底细胞瘤，预后大多良好。内分泌细胞散在于大多数常见的前列腺癌中。因此，可能会出现同时具有常见腺癌和类癌成分的混合形式。前列腺纯类癌是罕见的发现。前列腺小细胞癌是内分泌细胞类型的高恶性变体。免疫组织化学显示，内分泌肿瘤细胞中可检测到多种蛋白激素。伴有库欣综合征的异位促肾上腺皮质激素分泌具有特殊的临床意义。
