腺嘌呤 A(2A)激动剂作为肾小球肾炎的治疗方法。
Adenosine A(2A) agonists as therapy for glomerulonephritis.
机构信息
Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.
出版信息
Kidney Int. 2011 Aug;80(4):329-31. doi: 10.1038/ki.2011.167.
PMID:21799503
Abstract
Garcia et al. report the utility of pharmacological activation of the adenosine A(2A) receptor (A(2A)R) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A(2A)R activation in determining outcome in renal inflammation is discussed.
摘要
加西亚等人报告了药理学激活腺苷 A（2A）受体（A（2A）R）在保护肾功能、逆转纤维化以及减少大鼠肾毒性肾炎中巨噬细胞浸润和炎症激活方面的作用。讨论了 A（2A）R 激活在决定肾脏炎症结局中的作用。
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