利培酮与氟西汀治疗儿童孤独症谱系障碍的开放标签试验。
An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder.
作者信息
Desousa Avinash
机构信息
Consultant Child and Adolescent Psychiatrist, Mumbai, India.
出版信息
Indian J Psychol Med. 2010 Jan;32(1):17-21. doi: 10.4103/0253-7176.70522.
OBJECTIVE
Various studies have shown the effectiveness of risperidone and fluoxetine in the management of behavioral problems in autism.
AIM
The purpose of this study was to compare these two drugs in the management of behavioral problems in autism.
MATERIALS AND METHODS
Forty children with autism were divided into 2 groups in a 16-week open trial that compared these two drugs. Parents rated the children using the Aberrant Behavior Checklist (ABC) and the Conners' Parent Rating Scale - Revised (CPRS-R). The author rated the children using the Children's Psychiatric Rating Scale and Clinical Global Impression (CGI) Scale.
RESULTS
The risperidone group showed significant improvement in areas like irritability and hyperactivity, while the fluoxetine group showed significant improvement in speech deviance, social withdrawal and stereotypy. When the two drugs were compared, fluoxetine showed greater improvement in stereotypy, while both drugs showed improvement on the general autism scale; and on anger, hyperactivity and irritability scales.
CONCLUSIONS
In this open trial, both drugs were well tolerated and appeared to be beneficial in the treatment of common behavioral problems in children with autism. Further controlled and double-blind studies in larger samples are warranted.
目的
多项研究已表明利培酮和氟西汀在治疗自闭症行为问题方面的有效性。
目的
本研究的目的是比较这两种药物在治疗自闭症行为问题方面的效果。
材料与方法
在一项为期16周的开放试验中，将40名自闭症儿童分为两组，对这两种药物进行比较。家长使用异常行为检查表（ABC）和修订版康纳斯父母评定量表（CPRS-R）对孩子进行评分。作者使用儿童精神病评定量表和临床总体印象（CGI）量表对孩子进行评分。
结果
利培酮组在易怒和多动等方面有显著改善，而氟西汀组在言语偏差、社交退缩和刻板行为方面有显著改善。当比较这两种药物时，氟西汀在刻板行为方面改善更大，而两种药物在总体自闭症量表以及愤怒、多动和易激惹量表上均有改善。
结论
在这项开放试验中，两种药物耐受性良好，似乎对治疗自闭症儿童的常见行为问题有益。有必要在更大样本中进行进一步的对照和双盲研究。
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