Department of Medical Sciences, Division of Endocrine Oncology, University Hospital of Uppsala, Uppsala 75900, Sweden.
World J Gastroenterol. 2011 Jul 7;17(25):3066-8. doi: 10.3748/wjg.v17.i25.3066.
There are four types of gastric carcinoid tumors, classified according to their histology and malignant potential. Only a few cases of carcinoid tumors in patients infected with Helicobacter pylori (H. pylori) have been reported so far. We report a patient infected with H. pylori presenting with a small solitary gastric carcinoid tumor with very low proliferative rate and normal gastrin levels. The tumor was endoscopically removed and the patient received an eradication therapy against H. pylori. No signs of metastatic disease have been found so far during more than 3 year of follow-up. Infection with H. pylori may cause chronic gastritis with normal or elevated gastrin levels, leading to the development of gastric carcinoids by mechanisms unrelated to gastrin. Enterochromaffin-like cell tumors related to a chronic H. pylori infection may be considered as a distinct type of gastric carcinoid tumors.
胃类癌肿瘤有四种类型，根据其组织学和恶性潜能进行分类。到目前为止，只有少数感染幽门螺杆菌 (H. pylori) 的类癌肿瘤病例报告。我们报告了一例感染 H. pylori 的患者，其表现为一个体积小且单发的胃类癌肿瘤，其增殖率非常低，胃泌素水平正常。肿瘤通过内镜切除，患者接受了针对 H. pylori 的根除治疗。在超过 3 年的随访中，目前尚未发现转移疾病的迹象。H. pylori 感染可导致伴有正常或升高胃泌素水平的慢性胃炎，从而通过与胃泌素无关的机制导致胃类癌肿瘤的发展。与慢性 H. pylori 感染相关的肠嗜铬样细胞肿瘤可能被认为是一种独特类型的胃类癌肿瘤。
