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伴有幽门螺杆菌相关慢性胃炎的胃神经内分泌肿瘤

Gastric neuroendocrine tumor with Helicobacter pylori-associated chronic gastritis.

作者信息

Serio Giovanni, Dell'Anna Armando, Debenedittis Anna, Stasi Elisa, Cascarano Maria Arcangela

机构信息

Unit of Anatomic Pathology, Vito Fazzi Hospital, Lecce, Italy.

Unit of Digestive Endoscopy, Vito Fazzi Hospital, Lecce, Italy.

出版信息

Int J Surg Case Rep. 2020;75:361-366. doi: 10.1016/j.ijscr.2020.09.081. Epub 2020 Sep 15.

DOI:10.1016/j.ijscr.2020.09.081
PMID:32980709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7522572/
Abstract

INTRODUCTION

Development of gastric neuroendocrine neoplasms in subjects infected with Helicobacter pylori is rare and it occurs through pathogenetic mechanisms related to gastrin.

PRESENTATION OF CASE

We report a case of gastric neuroendocrine tumor in a patient infected with Helicobacter pylori and normal gastrin levels. He was treated by endoscopic mucosal dissection after eradication of Helicobacter pylori infection. Histologically the tumor was consistent with a grade 2 well differentiated neuroendocrine tumor. It was characterized by the presence of lymphoid aggregates around and inside the neoplasia.

DISCUSSION

Helicobacter pylori-associated chronic gastritis can rarely cause the development of gastric neuroendocrine tumors through mechanisms unrelated to gastrin.

CONCLUSION

The one related to a chronic Helicobacter pylori infection may be considered a distinct type of gastric neuroendocrine tumor.

摘要

引言

幽门螺杆菌感染患者发生胃神经内分泌肿瘤较为罕见，其通过与胃泌素相关的发病机制出现。

病例介绍

我们报告一例幽门螺杆菌感染且胃泌素水平正常的患者发生胃神经内分泌肿瘤。在根除幽门螺杆菌感染后，他接受了内镜黏膜下剥离术治疗。组织学检查显示肿瘤符合2级高分化神经内分泌肿瘤。其特征为肿瘤周围和内部存在淋巴样聚集物。

讨论

幽门螺杆菌相关性慢性胃炎很少通过与胃泌素无关的机制导致胃神经内分泌肿瘤的发生。

结论

与慢性幽门螺杆菌感染相关的情况可被视为一种独特类型的胃神经内分泌肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/0c8434ea0114/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/d22eaedb367f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/63debc8d8b59/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/228305c1f32b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/b44ebbabeb22/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/db18719aedb4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/0c8434ea0114/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/d22eaedb367f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/63debc8d8b59/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/228305c1f32b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/b44ebbabeb22/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/db18719aedb4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd26/7522572/0c8434ea0114/gr5.jpg

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