World J Gastroenterol. 2011 Jul 7;17(25):3073-4. doi: 10.3748/wjg.v17.i25.3073.
Biliary cystic tumors, such as cystadenomas and cystadenocarcinomas, are rare cystic tumors of the liver, accounting for less than 5% of all intrahepatic cysts of biliary origin. Biliary cystadenomas have been known to occur predominantly in women (> 85%), and 38%-44% of biliary cystadenocarcinomas have occurred in males. We wrote this letter to comment on a brief article (World J Gasteroenterol 2011 January 21; 17(3): 361-365) regarding a case of intrahepatic biliary cystic neoplasm treated with surgery. The adenoma-carcinoma sequence is the possible mechanism of carcinogenesis. If the carcinogenesis of biliary cystadenocarcinoma occurs in the adenoma-carcinoma sequence, we believe that the male-to-female ratio of cystadenoma should be higher than the incidence rate that has been reported to date.
胆管囊性肿瘤，如囊腺瘤和囊腺癌，是肝脏罕见的囊性肿瘤，占所有胆管来源的肝内囊肿的不到 5%。胆管囊腺瘤主要发生在女性（>85%），而胆管囊腺癌的 38%-44%发生在男性。我们写这封信是为了评论一篇关于手术治疗肝内胆管囊性肿瘤病例的简短文章（世界胃肠病学杂志 2011 年 1 月 21 日；17(3):361-365）。腺瘤-癌序列是可能的致癌机制。如果胆管囊腺癌的发生遵循腺瘤-癌序列，我们认为囊腺瘤的男女比例应该高于目前报道的发病率。
