Shi Bin, Yu Peng, Meng Lingzhan, Li Hu, Wang Zizheng, Cao Li, Yan Jin, Shao Yanling, Zhang Ying, Zhu Zhenyu
Department of Organ Transplantation, The Third Medical Center of PLA General Hospital, Beijing, China.
Department of Hepatology Surgery, The Fifth Medical Center of the PLA General Hospital, Beijing, China.
Sci Rep. 2024 Jul 17;14(1):16507. doi: 10.1038/s41598-024-67320-2.
This study comprehensively explores the clinical characteristics, diagnostic approaches, and treatment methods for liver mucinous cystic neoplasms (MCN). A retrospective analysis was conducted on seven individuals diagnosed with MCN, admitted to the Fifth Medical Center of the PLA General Hospital between October 2016 and May 2023. Preoperative AFP was negative, while CA19-9 was elevated in two cases. Surgical resection was performed for all patients. The patients showed favorable postoperative recovery. Follow-up revealed an excellent overall survival rate, except for one case of invasive carcinoma resulting in tumor recurrence and metastasis 6 months after surgery. MCN poses a diagnostic challenge due to the absence of distinct clinical and radiological features, leading to potential misdiagnosis and inappropriate treatment. Patients with suspected liver cystic diseases should consider the possibility of MCN. Surgical resection has proven to be a practical approach with satisfactory therapeutic outcomes.
本研究全面探讨了肝脏黏液性囊性肿瘤(MCN)的临床特征、诊断方法和治疗手段。对2016年10月至2023年5月期间解放军总医院第五医学中心收治的7例诊断为MCN的患者进行了回顾性分析。术前甲胎蛋白(AFP)为阴性,而糖类抗原19-9(CA19-9)在2例中升高。所有患者均接受了手术切除。患者术后恢复良好。随访显示总体生存率良好,除1例侵袭性癌患者术后6个月出现肿瘤复发和转移。由于缺乏明显的临床和影像学特征,MCN带来了诊断挑战,可能导致误诊和不恰当的治疗。疑似肝脏囊性疾病的患者应考虑MCN的可能性。手术切除已被证明是一种切实可行的方法,治疗效果令人满意。