Nader S
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Medical School, Houston 77030.
Semin Perinatol. 1990 Feb;14(1):24-33.
In conclusion, the physiologic changes that occur in the pituitary during pregnancy make women harboring pituitary tumors more vulnerable to tumor complications, namely tumor expansion resulting in either visual defects or hormone deficiencies. Fortunately, vast experience with the most common of these tumors (prolactinomas) allows us to make specific recommendations to women with such tumor embarking upon pregnancy. These recommendations have been outlined. In addition to tumors, the anterior lobe of the pituitary may be the seat of two rare conditions (Sheehan's syndrome and lymphocytic hypophysitis) that afflict pregnant women predominantly. Their importance lies in the fact that hypopituitarism, sometimes requiring urgent treatment, may result. Finally, pregnancy may have an unfavorable impact upon women with diabetes insipidus, necessitating careful observation. Given the availability of a specific and highly effective therapeutic agent, desmopressin acetate, the management of these women is rarely problematic.
总之，孕期垂体发生的生理变化使患有垂体肿瘤的女性更容易出现肿瘤并发症，即肿瘤扩大导致视力缺陷或激素缺乏。幸运的是，对这些最常见肿瘤（催乳素瘤）的丰富经验使我们能够为怀有此类肿瘤并准备怀孕的女性提供具体建议。这些建议已列出。除肿瘤外，垂体前叶可能是两种主要困扰孕妇的罕见病症（席汉综合征和淋巴细胞性垂体炎）的发病部位。它们的重要性在于可能导致垂体功能减退，有时需要紧急治疗。最后，妊娠可能对患有尿崩症的女性产生不利影响，需要仔细观察。鉴于有特效且高效的治疗药物醋酸去氨加压素，对这些女性的管理很少出现问题。
