Molitch M E
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
Endocrinol Metab Clin North Am. 1993 Sep;22(3):649-72.
A number of changes in renal and endocrine physiology occur during pregnancy that alter hormone levels and affect a number of disease processes. Increased glomerular filtration causes an increase in hormone and substrate clearance. Increased placental steroid production causes an increase in hormone-binding globulin production, insulin resistance, and prolactinoma growth. Production of peptide hormones may cause changes in normal physiology and alter dynamic hormone testing. Placental vasopressinase increases vasopressin clearance. A number of diseases of hormone overproduction and underproduction affect pregnancy outcome and must be treated promptly by therapeutic modalities that also may affect the fetus.
孕期肾脏和内分泌生理会发生一些变化，这些变化会改变激素水平并影响多种疾病进程。肾小球滤过增加导致激素和底物清除增加。胎盘类固醇生成增加导致激素结合球蛋白生成增加、胰岛素抵抗和催乳素瘤生长。肽类激素的产生可能会导致正常生理发生变化并改变动态激素检测结果。胎盘血管加压素酶增加血管加压素清除率。多种激素分泌过多和分泌不足的疾病会影响妊娠结局，必须通过可能也会影响胎儿的治疗方式及时治疗。
