手性磺酰亚胺作为布朗斯特酸有机催化剂用于吲哚与亚胺的不对称傅克烷基化反应。
Chiral sulfonimide as a Brønsted acid organocatalyst for asymmetric Friedel-Crafts alkylation of indoles with imines.
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.
出版信息
J Org Chem. 2011 Sep 2;76(17):7141-7. doi: 10.1021/jo2011335. Epub 2011 Aug 9.
PMID:21800841
Abstract
Binaphthyl-based chiral sulfonimide (CSI) is demonstrated for the first time to be an efficient, strong Brønsted acid in asymmetric organocatalysis. A series of CSIs were synthesized and screened in the asymmetric Friedel-Crafts alkylation of indoles with imines. Good to excellent yields and enantioselectivities have been achieved. It was proved that it was crucial to wash the CSI catalyst with HCl before use.
摘要
手性联萘基磺酰亚胺（CSI）首次被证明是不对称有机催化中一种高效、强布朗斯特酸。一系列 CSI 被合成并用于吲哚与亚胺的不对称傅克烷基化反应中进行筛选。获得了良好至优秀的产率和对映选择性。证明在使用 CSI 催化剂之前用盐酸洗涤是至关重要的。
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