School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
J Org Chem. 2011 Sep 2;76(17):7216-21. doi: 10.1021/jo2008127. Epub 2011 Aug 9.
The marine natural product 16-deacetoxy-12-epi-scalarafuranacetate, isolated from Spongua officinalis , was synthesized in 18 linear steps, starting from (-)-sclareol, with high stereoselectivity and an overall yield of 6.1%. The intermediate 16-deacetoxy-12-epi-scalarafuran could be easily transformed into a series of natural scalarane sesterterpenoids in a few steps.
从(-)-喇叭醇出发，经 18 步线性反应，以 6.1%的总收率立体选择性地合成了海洋天然产物 16-去乙酰氧基-12-表-斯卡夫拉烷乙酸酯，该产物可由中间体 16-去乙酰氧基-12-表-斯卡夫拉烷几步转化为一系列天然的螺甾烷倍半萜。
