通过树状大分子模板化肽两亲分子自组装设计具有生物活性的类似蛋白纳米球。
De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly.
机构信息
Department of Chemistry and Biochemistry, Materials Research Laboratory, University of California, Santa Barbara, California 93106, United States.
出版信息
Nano Lett. 2011 Sep 14;11(9):3946-50. doi: 10.1021/nl202220q. Epub 2011 Aug 3.
Abstract
Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.
摘要
自组装肽两亲物（PAs）已广泛应用于新型生物材料的开发。由于其易于形成圆柱状胶束，因此在需要小的球形胶束的应用中受到限制。在这里，我们提出了一种平台方法，使用树枝状大分子作为形状导向支架来控制生物功能化 PA 自组装成 50nm 的球形颗粒。这种模板方法得到了具有生物相容性的、稳定的类蛋白组装体，展示了具有天然二级结构和生物功能的肽。
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