Friggi A, Chevalier-Cholat A M, Torresani J
Eur J Pharmacol. 1977 Oct 1;45(3):295-300. doi: 10.1016/0014-2999(77)90013-9.
Blood pressure and peripheral resistance were reduced, baroreceptor activity was enhanced after i.v. infusion of beta-adrenoceptor blocking agents in rabbits with intact circulation or with total cardiopulmonary bypass. The latter preparation allowed cardiac effects of the drugs to be excluded. In rabbits with an intact circulation, post-ganglionic sympathetic activity was reduced. These results suggest a direct vascular action of the drugs. The increased baroreceptor firing is not a cardiac-mediated effect and may partly induce the observed reduction in sympathetic activity.
在循环完整或进行全心肺转流的家兔中，静脉输注β-肾上腺素受体阻断剂后，血压和外周阻力降低，压力感受器活动增强。后一种制备方法可排除药物对心脏的影响。在循环完整的家兔中，节后交感神经活动降低。这些结果提示药物具有直接的血管作用。压力感受器放电增加不是心脏介导的效应，可能部分导致了观察到的交感神经活动降低。
