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β-肾上腺素能受体阻滞剂对兔血流动力学变量、压力感受器及节后交感神经活动的作用

Action of beta-adrenoceptor blocking agents on hemodynamic variables and on baroreceptor and postganglionic sympathetic activities in rabbits.

作者信息

Chevalier-Cholat A M, Friggi A, Torresani J

出版信息

Biomedicine. 1978 Jan-Feb;28(1):67-72.

PMID:27257
Abstract

Fifty-six experiments were performed in rabbits anesthetized by urethane or sodium pentobarbital. Baroreceptor (aortic nerve) and post-ganglionic sympathetic (renal nerve) activities were recorded, and peripheral resistances were determined after infusion of beta-adrenoceptor blocking agents (propranolol, pindolol, timolol). A progressive vasodilation was observed after the onset of infusion of the 3 drugs; at the same time arterial pressure decreased, but aortic flow did not vary significantly. Baroreceptor activity was enhanced, whereas efferent renal nerve activity was decreased.

摘要

在由氨基甲酸乙酯或戊巴比妥钠麻醉的兔子身上进行了56次实验。记录压力感受器(主动脉神经)和节后交感神经(肾神经)的活动,并在输注β-肾上腺素能受体阻滞剂(普萘洛尔、吲哚洛尔、噻吗洛尔)后测定外周阻力。在输注这3种药物后观察到进行性血管舒张;同时动脉压下降,但主动脉血流量无显著变化。压力感受器活动增强,而肾神经传出活动减少。

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Action of beta-adrenoceptor blocking agents on hemodynamic variables and on baroreceptor and postganglionic sympathetic activities in rabbits.β-肾上腺素能受体阻滞剂对兔血流动力学变量、压力感受器及节后交感神经活动的作用
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引用本文的文献

1
Baroreceptor and sympathetic responses to acebutolol, a beta 1-adrenoceptor-blocking agent, in rabbits.
Experientia. 1979 May 15;35(5):646-7. doi: 10.1007/BF01960375.