自体全血和自体血清注射与安慰剂注射在降低慢性自发性荨麻疹患者的疾病活动度方面同样有效：一项安慰剂对照、随机、单盲研究。
Autologous whole blood and autologous serum injections are equally effective as placebo injections in reducing disease activity in patients with chronic spontaneous urticaria: a placebo controlled, randomized, single-blind study.
机构信息
Goztepe Training and Research Hospital, Department of Dermatology, İstanbul, Turkiye.
出版信息
J Dermatolog Treat. 2012 Dec;23(6):465-71. doi: 10.3109/09546634.2011.593485. Epub 2011 Jul 31.
BACKGROUND
Recent demonstration of circulating anti-IgG antibodies towards IgE and its receptor (FcϵRI) has led to an interest in inducing tolerance to circulating histamine-releasing factors with autologous blood injections as a treatment option in chronic spontaneous urticaria (CU). The aim of the study was to assess the efficacy of autologous whole blood (AWB) and autologous serum (AS) injections in patients with CU compared to placebo.
METHODS
A total of 88 CU patients with (+) autologous serum skin test (ASST) (59) and (-) ASST (29) were randomized into three parallel subgroups and were treated with weekly injections of AWB, AS or placebo for 10 weeks. Clinical assessments included urticaria activity score (UAS) and dermatology life quality index.
RESULTS
In ASST (+) patients, the percentages of patients with >30% improvement in UAS and DLQI were 85% and 90% in AWB group, 65% and 65% in AS group and 79% and 90% in placebo group, respectively. In ASST (-) patients, these figures were 67% and 89% in the AWB group, 80% and 80% in the AS group and 60% and 70% in the placebo group. The intergroup difference for complete subsidence was not statistically significant.
CONCLUSIONS
Even though we could not show a better efficacy than placebo, autohemotherapy resulted in a marked decrease in disease activity and improvement in quality of life scores in CU patients.
背景
最近有研究表明，循环中的抗 IgE 及其受体（FcϵRI）抗体可诱导对循环中释放组胺的因子产生耐受性，自体血注射可能成为慢性自发性荨麻疹（CSU）的一种治疗选择。本研究旨在评估自体全血（AWB）和自体血清（AS）注射治疗 CSU 患者的疗效，并与安慰剂进行比较。
方法
共纳入 88 例 CSU 患者，其中自体血清皮肤试验（ASST）阳性（59 例）和阴性（29 例），随机分为三组，每周接受 AWB、AS 或安慰剂治疗 10 周。临床评估包括荨麻疹活动评分（UAS）和皮肤病生活质量指数（DLQI）。
结果
在 ASST 阳性患者中，AWB 组 UAS 和 DLQI 改善 >30%的患者比例分别为 85%和 90%，AS 组分别为 65%和 65%，安慰剂组分别为 79%和 90%。在 ASST 阴性患者中，AWB 组 UAS 和 DLQI 改善 >30%的患者比例分别为 67%和 89%，AS 组分别为 80%和 80%，安慰剂组分别为 60%和 70%。各组间完全缓解的差异无统计学意义。
结论
尽管我们未能显示出优于安慰剂的疗效，但自体血疗法可显著降低 CSU 患者的疾病活动度，改善生活质量评分。
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