慢性自发性荨麻疹的皮下自体血清疗法
Subcutaneous Autologous Serum Therapy in Chronic Spontaneous Urticaria.
作者信息
Godse Kiran Vasant, Nadkarni Nitin, Patil Sharmila, Mehta Aayushi
机构信息
Department of Dermatology, D. Y. Patil Hospital, Navi Mumbai, Maharashtra, India.
出版信息
Indian J Dermatol. 2017 Sep-Oct;62(5):505-507. doi: 10.4103/ijd.IJD_710_16.
BACKGROUND
There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its efficacy by subcutaneous route.
AIMS
To evaluate the effectiveness of subcutaneous autologous serum therapy (AST) in CSU.
METHODS
This was a single blind, placebo-controlled parallel group, randomized, controlled study. Twenty-four patients with CSU (11M: 13 F) were given subcutaneous AST and seventeen patients (7 M: 10F) patients were given subcutaneous injection normal saline (placebo), along with levocetirizine in an on-demand basis in both groups.
RESULTS
Urticaria activity score (UAS) came down from 35.74 to 7 at the end of 9 weeks and the patients' requirement of antihistamines also reduced remarkably from 5.8 to 1.7 per week in the serum group. Sub-cutaneous saline group did not show statistically significant fall in UAS. Saline group showed UAS 32.8 at zero week to 22.1 at the end of 9 weeks. DLQI showed significant fall in serum group, from 14.26 to 4 at the end of 9 weeks.
CONCLUSION
Subcutaneous autoserum therapy is effective in treatment of CSU.
背景
对于慢性自发性荨麻疹患者，尤其是那些被归类为对抗组胺药无反应的患者亚组，人们迫切需要尝试更新的治疗方法。自体血清疗法是一种新兴的治疗方式，我们决定研究其皮下注射途径的疗效。
目的
评估皮下自体血清疗法（AST）治疗慢性自发性荨麻疹（CSU）的有效性。
方法
这是一项单盲、安慰剂对照的平行组随机对照研究。24例慢性自发性荨麻疹患者（11例男性：13例女性）接受皮下AST治疗，17例患者（7例男性：10例女性）接受皮下注射生理盐水（安慰剂），两组均按需给予左西替利嗪。
结果
血清组荨麻疹活动评分（UAS）在9周结束时从35.74降至7，患者每周对抗组胺药的需求量也从5.8显著降至1.7。皮下生理盐水组UAS未出现统计学上的显著下降。生理盐水组UAS在第0周为32.8，在9周结束时为22.1。皮肤病生活质量指数（DLQI）在血清组显著下降，在9周结束时从14.26降至4。
结论
皮下自体血清疗法治疗慢性自发性荨麻疹有效。
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