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纳米技术平台;脑肿瘤治疗的创新方法。

Nanotechnology platforms; an innovative approach to brain tumor therapy.

机构信息

Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.

出版信息

Med Chem. 2011 Sep;7(5):488-503. doi: 10.2174/157340611796799113.

Abstract

Nano Drug Delivery, as a treatment method against brain tumors, is a progressing area in the field of precise targeted drug administration methodology. The unresolved problems related to chemotherapy, other invasive therapeutic procedures and various obstructions offered by biological barriers are circumvented by nanodrug delivery. Recent dramatic developments in nanotechnology have created a lot of nano-devices which could be used against cancer. Infiltration, modulation of the Blood Brain Barrier, camouflaged from immune defense mechanism and the specific targeting of cancer affected cells are a few of the attractive features of nanodevices. We present here a review of newly evolved nanoplatforms in brain tumor therapy in which careful attention has been paid into various form nanoparticles, useful targeting ligands, altered chemotherapy agents and existing tumor therapy methods using nanotechnology.

摘要

纳米药物递送作为一种治疗脑肿瘤的方法,是精准靶向药物给药方法领域的一个研究热点。纳米药物递送绕过了与化疗、其他侵入性治疗程序以及生物屏障带来的各种障碍相关的未解决问题。纳米技术的最新显著发展创造了许多可用于抗癌的纳米设备。渗透、血脑屏障的调节、免疫防御机制的伪装以及对受癌症影响的细胞的特异性靶向是纳米设备的一些有吸引力的特征。我们在这里综述了新出现的用于脑肿瘤治疗的纳米平台,其中仔细关注了各种形式的纳米颗粒、有用的靶向配体、改良的化疗药物以及使用纳米技术的现有肿瘤治疗方法。

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