Afschrift M
Dienst Geriatrie, Universitair Ziekenhuis, Gent, België.
Tijdschr Gerontol Geriatr. 1990 Feb;21(1):3-6.
Thyroid dysfunction in the elderly differs from that in the young, because most symptoms at presentation are absent, or non specific or atypical. Hypothyroid patients generally present with cardiovascular or central nervous system symptoms. A serious complication, occurring more easily in elderly is hypothyroid coma. The diagnosis of hypothyroidism is confirmed by a high serum TSH and low values of FT4 and T4. Elderly patients should be started on low doses of thyroid-hormone replacement that are increased slowly. Particular caution must be used in patients with underlying cardiovascular disease. Hyperthyroid patients are more likely to show cardiovascular symptoms, central nervous system symptoms or gastrointestinal symptoms. The diagnosis is confirmed by a low serum TSH value and elevated values for the serum FT4 and/or T3. Radioiodine (131I) therapy is the most efficient treatment in this age group. A diffusely enlarged thyroid gland in the elderly is most often caused by a multinodular goiter. Solitary thyroid nodules which appear cold on isotope scan may represent a carcinoma. The diagnosis of malignancy can be made after fine needle-aspiration of the nodule.
老年人的甲状腺功能障碍与年轻人不同,因为大多数就诊时的症状不存在、不特异或不典型。甲状腺功能减退患者通常表现为心血管或中枢神经系统症状。一种更易在老年人中发生的严重并发症是甲状腺功能减退昏迷。甲状腺功能减退的诊断通过高血清促甲状腺激素(TSH)以及低游离甲状腺素(FT4)和甲状腺素(T4)值来确诊。老年患者应从低剂量的甲状腺激素替代治疗开始,并缓慢增加剂量。对于有潜在心血管疾病的患者必须格外谨慎。甲状腺功能亢进患者更可能表现出心血管症状、中枢神经系统症状或胃肠道症状。诊断通过低血清TSH值以及血清FT4和/或T3值升高来确诊。放射性碘(131I)治疗是该年龄组最有效的治疗方法。老年人甲状腺弥漫性肿大最常见的原因是多结节性甲状腺肿。同位素扫描显示为冷结节的孤立性甲状腺结节可能是癌。结节细针穿刺后可做出恶性肿瘤的诊断。