Department of Nephrology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Clin Chim Acta. 2011 Oct 9;412(21-22):1983-8. doi: 10.1016/j.cca.2011.07.014. Epub 2011 Jul 23.
Metabolic syndrome is a common risk factor for cardiovascular disease. Chronic kidney disease (CKD) is a worldwide public health problem. We investigated the association between metabolic syndrome and CKD in a rural Chinese population.
This was a cross-sectional study using data from the Handan Eye Study.
4944 of participants aged ≥ 30 y were included in this analysis. Participants with metabolic syndrome had a higher prevalence of CKD (20.9% vs.15.8%, P<0.001) than those without. As the number of metabolic syndrome components increased, so did the prevalence of CKD (P<0.001). The multivariate-adjusted odds ratio (OR) of chronic kidney disease in participants with metabolic syndrome was 1.293 (95% CI 1.093-1.529) compared with those without. In multivariate logistic regression analysis, high blood pressure (OR 1.348; 95% CI 1.122-1.619) and high fasting glucose (OR 1.501; 95% CI 1.235-1.794) were independently associated with the risk for CKD. Compared with participants without any component, multivariate adjusted OR for CKD was 1.316 (95%CI 1.004-1.723), 1.397(95%CI 1.038-1.882), 1.672 (95%CI 1.183-2.363) for those with 2, 3, 4 or 5 components, respectively.
In this rural Chinese population aged ≥ 30 y, metabolic syndrome was associated with CKD.
代谢综合征是心血管疾病的常见危险因素。慢性肾脏病（CKD）是一个全球性的公共卫生问题。我们在一个农村中国人群中研究了代谢综合征与 CKD 之间的关系。
这是一项使用邯郸市眼病研究数据的横断面研究。
本分析纳入了 4944 名年龄≥30 岁的参与者。患有代谢综合征的参与者 CKD 患病率（20.9%比 15.8%，P<0.001）高于无代谢综合征的参与者。随着代谢综合征成分数量的增加，CKD 的患病率也随之增加（P<0.001）。与无代谢综合征的参与者相比，患有代谢综合征的参与者发生慢性肾脏病的多变量调整比值比（OR）为 1.293（95%CI 1.093-1.529）。在多变量逻辑回归分析中，高血压（OR 1.348；95%CI 1.122-1.619）和高空腹血糖（OR 1.501；95%CI 1.235-1.794）与 CKD 的风险独立相关。与无任何成分的参与者相比，多变量调整后 CKD 的 OR 分别为 1.316（95%CI 1.004-1.723）、1.397（95%CI 1.038-1.882）、1.672（95%CI 1.183-2.363），分别为存在 2、3、4 或 5 个成分的参与者。
在这个≥30 岁的农村中国人群中，代谢综合征与 CKD 相关。
