Yang Tsan, Chou Yu-Ching, Chu Chi-Hong, Lin Shih-Hua, Hsieh Po-Chien, Hsu Chih-Hsung, Bai Chyi-Huey, You San-Lin, Sun Chien-An
Department of Health Business Administration, Meiho University , Pingtung County , Taiwan .
Endocr Res. 2014;39(3):94-8. doi: 10.3109/07435800.2013.840652. Epub 2013 Oct 23.
Inflammation is a common phenotype for cardiometabolic disorders. In this study, we attempted to investigate inter-relationships between metabolic syndrome (MetS), C-reactive protein (an inflammatory biomarker) and chronic kidney disease (CKD). We performed a cross-sectional analysis of data from a representative sample of 4425 Chinese adults in Taiwan. The MetS was defined by a unified criteria set by several major organizations. A CKD event was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2). Additionly, a CRP cutpoint of 3 mg/L was used to differentiate high and low CRP levels. Overall, 1000 participants had MetS, resulting in a prevalence rate of 22.6%. High CRP level was noted in 782 (17.6%) subjects. In addition, a total of 508 (11.5%) persons qualified as having CKD. Subjects with the MetS had 1.55-fold [95% confidence interval (CI), 1.03-2.32] increased odds of CKD compared with their counterparts without the MetS after multiple adjustments. In addition, there was a significantly graded relationship between increasing levels of serum CRP and prevalent CKD (p for trend = 0.001). Participants in the highest category of serum CRP had a significantly elevated odds of CKD as compared with those in the lowest category [odds ratio (OR), 1.60; 95% CI, 1.21-2.12]. However, there was no interaction in excess of additive scale between the presence of MetS and high CRP level (p = 0.83). These findings suggest that MetS and high CRP were independently associated with increased prevalence of CKD in Chinese adults.
炎症是心脏代谢紊乱的常见表型。在本研究中，我们试图探究代谢综合征（MetS）、C反应蛋白（一种炎症生物标志物）与慢性肾脏病（CKD）之间的相互关系。我们对来自台湾4425名中国成年人的代表性样本数据进行了横断面分析。MetS由几个主要组织设定的统一标准定义。CKD事件定义为估算肾小球滤过率（eGFR）<60 mL/（min·1.73 m²）。此外，采用3 mg/L的CRP切点来区分高CRP水平和低CRP水平。总体而言，1000名参与者患有MetS，患病率为22.6%。782名（17.6%）受试者CRP水平较高。此外，共有508名（11.5%）人符合CKD诊断标准。在进行多次调整后，患有MetS的受试者发生CKD的几率是未患MetS者的1.55倍[95%置信区间（CI），1.03 - 2.32]。此外，血清CRP水平升高与CKD患病率之间存在显著的分级关系（趋势p值 = 0.001）。血清CRP最高组的参与者发生CKD的几率显著高于最低组[比值比（OR），1.60；95% CI，1.21 - 2.12]。然而，MetS的存在与高CRP水平之间不存在超过相加尺度的相互作用（p = 0.83）。这些发现表明，MetS和高CRP水平与中国成年人CKD患病率增加独立相关。
