Bakhle Y S, Smith T W
Eur J Pharmacol. 1977 Nov 1;46(1):31-9. doi: 10.1016/0014-2999(77)90141-8.
Tryptamine and 5-hydroxytryptamine (5-HT) infused through the pulmonary circulation of rat isolated lungs released a spasmogen resembling slow reacting substance of anaphylaxis which we have denoted SRS-T and a PGE-like activity. SRS-T was not extractable from Krebs solution by several organic solvents at neutral or acid pH. It is therefore unlike other types of SRS activity. The PGE-like release had a threshold at about 2 microgram/ml of tryptamine or 5-HT and did not increase with increasing doses (up to 10 microgram/ml); this release was abolished by methysergide, BC 105 and BW 501c67 but not by morphine. Comparison of agonist potencies of 5-HT and tryptamine on rat stomach strip and rat pulmonary artery and of antagonist potencies of methysergide, BC 105 and morphine on these tryptamine receptors lead to the conclusion that the release receptors are unlike either of the myotropic receptors. In terms of antagonist specificity the release receptors are closest to those in rat stomach strip.
通过大鼠离体肺的肺循环注入色胺和5-羟色胺（5-HT），可释放出一种类似过敏反应慢反应物质的致痉原，我们将其命名为SRS-T，并释放出一种类似前列腺素E的活性物质。在中性或酸性pH条件下，几种有机溶剂无法从 Krebs 溶液中提取出SRS-T。因此，它与其他类型的SRS活性不同。类似前列腺素E的释放量在色胺或5-HT约为2微克/毫升时有一个阈值，且不会随着剂量增加（高达10微克/毫升）而增加；这种释放可被麦角新碱、BC 105和BW 501c67阻断，但不能被吗啡阻断。比较5-HT和色胺对大鼠胃条和大鼠肺动脉的激动剂效力，以及麦角新碱、BC 105和吗啡对这些色胺受体的拮抗剂效力，得出的结论是，释放受体与两种肌动性受体均不同。就拮抗剂特异性而言，释放受体与大鼠胃条中的受体最为接近。
