Bakhle Y S, Smith T W
Br J Pharmacol. 1974 Jul;51(3):459-61. doi: 10.1111/j.1476-5381.1974.tb10684.x.
Tryptamine and 5-hydroxytryptamine (5-HT) are equipotent in contracting spiral strips of rat isolated pulmonary artery, in doses between 5 and 20 mug. These 5-HT receptors are blocked by low concentrations (c. 10(-9) M) of both methysergide and morphine. In rat isolated lung perfused via the pulmonary circulation, 5-HT caused increases in perfusion pressure which were also antagonized by methysergide and by morphine. These vascular 5-HT receptors cannot therefore be classified as M or D receptors and, furthermore, are different from those 5-HT receptors mediating release of spasmogens from rat isolated lungs.
色胺和5-羟色胺（5-HT）在5至20微克的剂量下，对收缩大鼠离体肺动脉螺旋条具有同等效力。这些5-HT受体可被低浓度（约10⁻⁹ M）的麦角新碱和吗啡阻断。在通过肺循环灌注的大鼠离体肺中，5-HT导致灌注压升高，这也被麦角新碱和吗啡所拮抗。因此，这些血管5-HT受体不能归类为M或D受体，此外，它们与介导大鼠离体肺释放致痉物质的5-HT受体不同。
