Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Am J Obstet Gynecol. 2011 Dec;205(6):518-25. doi: 10.1016/j.ajog.2011.05.042. Epub 2011 Jun 7.
Worldwide, obesity has become a major public health crisis. Overweight and obesity not only increase the risk of cardiovascular disease and type-2 diabetes mellitus but also are now known risk factors for a variety of cancer types. Among all cancers, increasing body mass index is associated most strongly with endometrial cancer incidence and death. The molecular mechanisms underlying how adipose tissue and obesity contribute to the pathogenesis of endometrial cancer are becoming better understood and have revealed a number of rational strategies, both behavioral and pharmaceutical, for the prevention of both primary and recurrent disease.
在全球范围内,肥胖已成为一个主要的公共卫生危机。超重和肥胖不仅增加了心血管疾病和 2 型糖尿病的风险,而且现在已知是多种癌症类型的危险因素。在所有癌症中,体重指数的增加与子宫内膜癌的发病率和死亡率关联最为密切。脂肪组织和肥胖导致子宫内膜癌发病机制的分子机制正在得到更好的理解,并揭示了一些合理的策略,包括行为和药物,以预防原发性和复发性疾病。