Institute o Pathological Physiology, Faculty of Medcine, Masaryk University, Brno, Czech Republic.
Neoplasma. 2011;58(2):124-8. doi: 10.4149/neo_2011_02_124.
Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p <001). We also determined single nucleotide polymorphism -420C>G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects.
子宫内膜癌（CAE）是工业化国家最常见的妇科恶性肿瘤。最近，人们认为脂肪细胞因子抵抗素水平升高是胃癌、结肠癌和乳腺癌的一个危险因素，这种脂肪细胞因子由脂肪组织和巨噬细胞产生。迄今为止，尚无研究将抵抗素水平与子宫内膜癌联系起来。本病例对照研究的目的是确定血清循环抵抗素水平与子宫内膜癌患者抵抗素基因 -420C>G（rs3219175）变异之间的关系。本研究纳入了 37 名白种女性患者和 39 名健康对照者。年龄和 BMI 匹配的患者组（平均 24.2ng/ml）和对照组（平均 10.1ng/ml）之间的抵抗素水平差异具有统计学意义（p<0.01）。我们还确定了抵抗素基因内的单核苷酸多态性 -420C>G（rs3219175），但未发现抵抗素水平与所研究多态性之间存在显著相关性。此外，在所研究的组内，未观察到较高的抵抗素水平与 2 型糖尿病、体重指数、吸烟或年龄之间存在显著相关性。据我们所知，这是首次研究血清抵抗素水平与子宫内膜癌之间的关系的研究，我们的结果表明，与对照组相比，子宫内膜癌患者的循环抵抗素水平显著升高。
