University of Aarhus, Department of Psychology, Aarhus, Denmark.
Clin Psychol Rev. 2011 Aug;31(6):1032-40. doi: 10.1016/j.cpr.2011.05.002. Epub 2011 May 15.
Mindfulness-based cognitive therapy (MBCT) is a group-based clinical intervention program designed to reduce relapse or recurrence of major depressive disorder (MDD) by means of systematic training in mindfulness meditation combined with cognitive-behavioral methods.
By means of a meta-analysis to evaluate the effect of MBCT for prevention of relapse or recurrence among patients with recurrent MDD in remission.
Electronic databases were searched and researchers were contacted for further relevant studies. Studies were coded for quality. Meta-analyses were performed by means of the Cochrane Collaboration Review Manager 5.1.
Six randomized controlled trials with a total of 593 participants were included in the meta-analysis. MBCT significantly reduced the risk of relapse/recurrence with a risk ratio of 0.66 for MBCT compared to treatment as usual or placebo controls, corresponding to a relative risk reduction of 34%. In a pre-planned subgroup analysis the relative risk reduction was 43% for participants with three or more previous episodes, while no risk reduction was found for participants with only two episodes. In two studies, MBCT was at least as effective as maintenance antidepressant medication.
Results of this meta-analysis indicate that MBCT is an effective intervention for relapse prevention in patients with recurrent MDD in remission, at least in case of three or more previous MDD episodes.
正念认知疗法（MBCT）是一种基于小组的临床干预方案，旨在通过系统的正念冥想训练结合认知行为方法，减少复发性重度抑郁症（MDD）的复发或复发。
通过荟萃分析评估 MBCT 对缓解期复发性 MDD 患者预防复发或复发的效果。
电子数据库进行检索，并联系研究人员以获取其他相关研究。对研究进行编码以评估质量。使用 Cochrane 协作 Review Manager 5.1 进行荟萃分析。
共有 593 名参与者的 6 项随机对照试验纳入荟萃分析。与常规治疗或安慰剂对照组相比，MBCT 显著降低了复发/复发的风险，MBCT 的风险比为 0.66，相当于相对风险降低 34%。在预先计划的亚组分析中，对于有三个或更多既往发作的参与者，相对风险降低了 43%，而对于仅有两个发作的参与者则没有发现风险降低。在两项研究中，MBCT 至少与维持抗抑郁药物治疗同样有效。
这项荟萃分析的结果表明，MBCT 是缓解期复发性 MDD 患者预防复发的有效干预措施，至少在有三个或更多既往 MDD 发作的情况下是如此。
