Department of Community Health, Brown University, Providence, RI, USA.
Cancer Lett. 2011 Nov 28;310(2):216-21. doi: 10.1016/j.canlet.2011.07.007. Epub 2011 Jul 12.
Men are much more likely than women to develop head and neck squamous cell carcinoma (HNSCC), a discrepancy that is insufficiently explained by gender differences in smoking and alcohol consumption. It has been hypothesized that differential hormonal exposures may account for some of this risk but thus far the literature on female reproductive factors and HNSCC risk has been sparse. To address the association of HNSCC with female hormonal and reproductive factors, a case-control study was conducted on 149 women with head and neck cancer and 158 controls. After adjusting for potential confounding, postmenopausal women using female hormones for more than 5 years showed a borderline protective effect for HNSCC (adjusted OR = 0.47, 95% CI: 0.20-1.08), with a borderline trend across duration of use categories (P = 0.06). There was no association of HNSCC with age at menarche, hysterectomy/oophorectomy status, oral contraceptive use, history of fertility medication, or number of pregnancies, parity, or age at first pregnancy or live birth. The findings of this study do not support a link between HNSCC and reproductive factors, although the borderline association with HRT warrants further investigation.
男性比女性更容易患上头颈部鳞状细胞癌（HNSCC），这种差异不能仅用吸烟和饮酒等性别差异来解释。有人假设，不同的激素暴露可能是导致部分风险的原因，但迄今为止，关于女性生殖因素与 HNSCC 风险的文献还很少。为了研究 HNSCC 与女性激素和生殖因素的关联，对 149 名患有头颈部癌症的女性和 158 名对照进行了病例对照研究。在调整了潜在的混杂因素后，绝经后使用女性激素超过 5 年的女性患 HNSCC 的风险呈边缘性保护作用（调整后的 OR = 0.47，95%CI：0.20-1.08），且使用时间类别呈边缘性趋势（P = 0.06）。HNSCC 与初潮年龄、子宫切除术/卵巢切除术状况、口服避孕药使用、生育药物史或妊娠、产次、首次妊娠或活产年龄无关。本研究的结果不支持 HNSCC 与生殖因素之间存在关联，尽管 HRT 呈边缘关联，需要进一步研究。
