Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA.
Neuropsychologia. 2011 Oct;49(12):3164-77. doi: 10.1016/j.neuropsychologia.2011.07.015. Epub 2011 Jul 23.
We examined the neural correlates of specific (i.e., unique to time and place) and general (i.e., extended in or repeated over time) autobiographical memories (AMs) during their initial construction and later elaboration phases. The construction and elaboration of specific and general events engaged a widely distributed set of regions previously associated with AM recall. Specific (vs. general) event construction preferentially engaged prefrontal and medial temporal lobe regions known to be critical for memory search and retrieval processes. General event elaboration was differentiated from specific event elaboration by extensive right-lateralized prefrontal cortex (PFC) activity. Interaction analyses confirmed that PFC activity was disproportionately engaged by specific AMs during construction, and general AMs during elaboration; a similar pattern was evident in regions of the left lateral temporal lobe. These neural differences between specific and general AM construction and elaboration were largely unrelated to reported differences in the level of detail recalled about each type of event.
我们研究了特定（即时间和地点特有的）和一般（即随时间扩展或重复）自传记忆（AMs）在其初始构建和后续详细构建阶段的神经相关性。特定（相对于一般）事件的构建和详细构建优先涉及先前与 AM 回忆相关的广泛分布的区域。已知记忆搜索和检索过程对于记忆搜索和检索过程至关重要，特定事件的构建优先涉及前额叶和内侧颞叶区域。一般事件的详细构建与特定事件的详细构建区分开来，这是由于右外侧前额叶皮层（PFC）的广泛活动。交互分析证实，在构建过程中，PFC 活动会不成比例地参与特定的 AM，而在详细构建过程中则会参与一般的 AM；在左侧颞叶的区域中也出现了类似的模式。特定和一般 AM 构建和详细构建之间的这些神经差异在很大程度上与报告的关于每种类型事件的详细程度的差异无关。
