Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell Metab. 2011 Aug 3;14(2):151-3. doi: 10.1016/j.cmet.2011.07.007.
Protein acetylation now rivals phosphorylation in frequency of occurrence but is incompletely understood. A picture is presented in which protein acetylation is linked to available energy via the NAD-dependent deacetylases. This model suggests that protein acetylation regulates metabolic strategy and also helps store energy in cells.
蛋白质乙酰化的发生频率可与磷酸化相媲美，但目前仍不完全了解。本文提出了一个观点，即蛋白质乙酰化通过 NAD 依赖性脱乙酰酶与可用能量相关联。该模型表明，蛋白质乙酰化调节代谢策略，并有助于在细胞中储存能量。
