Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, China.
Am J Surg. 2012 Feb;203(2):217-21. doi: 10.1016/j.amjsurg.2010.10.022. Epub 2011 Jul 30.
In recent years, with social and economic development and lifestyle changes, the incidence of gastric cancer as well as the surgical results and prognoses of patients with gastric cancer have changed significantly in southeast China.
A total of 1,451 patients were divided into 2 groups according to admission time periods. Trends in clinicopathologic characteristics and operative outcomes of these patients were analyzed retrospectively.
The numbers of old and young patients were significantly increased in period 2 compared with period 1. Tumors located in the proximal stomach increased from 20.26% to 36.83%. The incidence of early gastric cancer was significantly increased from period 1 to period 2. Lymph node metastasis was seen more prevalently in period 2 than in period 1. The rate of operation-related major complications decreased from 5.23% to 1.43%. Operative mortality was .49% in period 1 and .24% in period 2. The 5-year survival rate increased from 38.40% to 53.99%.
Early diagnosis, standardized surgical treatment including pertinent lymph node dissection, and better perioperative care notably improve the outcomes of patients with gastric cancer.
近年来，随着社会经济发展和生活方式的改变，中国东南地区胃癌的发病率以及胃癌患者的手术结果和预后发生了显著变化。
根据入院时间将 1451 例患者分为 2 组，回顾性分析这些患者的临床病理特征和手术结果的变化趋势。
与第 1 期相比，第 2 期老年和年轻患者的数量明显增加。肿瘤位于近端胃的比例从 20.26%增加到 36.83%。早期胃癌的发病率从第 1 期到第 2 期显著增加。第 2 期淋巴结转移的发生率明显高于第 1 期。与手术相关的主要并发症发生率从 5.23%降至 1.43%。第 1 期手术死亡率为 0.49%，第 2 期为 0.24%。5 年生存率从 38.40%提高到 53.99%。
早期诊断、规范化的手术治疗包括相关淋巴结清扫术以及更好的围手术期护理显著改善了胃癌患者的预后。
