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Wnt10B对胃癌的进展至关重要。

Wnt10B is critical for the progression of gastric cancer.

作者信息

Wu Xiao-Dan, Bie Qing-Li, Zhang Bin, Yan Zi-He, Han Zhi-Jun

机构信息

Department of Laboratory Medicine, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, Jiangsu 214002, P.R. China.

The Key Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

出版信息

Oncol Lett. 2017 Jun;13(6):4231-4237. doi: 10.3892/ol.2017.5992. Epub 2017 Apr 5.

DOI:10.3892/ol.2017.5992
PMID:28599424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5452953/
Abstract

The family of Wnt proteins have been implicated in embryogenesis by regulation of cell fate and pattern formation, and also in human carcinogenesis. Wnt10B was previously shown to be involved in breast cancer development. The present study assessed the association of Wnt10B expression in human gastric cancer tissue specimens with clinicopathological data from these patients. Wnt10B expression in the regulation of gastric cancer cell proliferation and migration capacity was then investigated. The data revealed that Wnt10B mRNA and protein were upregulated in gastric cancer tissue samples and the upregulated Wnt10B mRNA was associated with gastric cancer metastasizing to lymph nodes. Knockdown of Wnt10B expression reduced gastric cancer cell proliferation and migration, as well as expression of a cell proliferation marker Ki67. Knockdown of Wnt10B expression inhibited tumor cell epithelial-mesenchymal transition by upregulation of E-cadherin and downregulation of N-cadherin. In addition, Wnt10B knockdown also suppressed tumor cell stemness by downregulation of octamer-binding transcription factor 4 and Nanog expression. The present data indicated that Wnt10B expression performs an important role in gastric cancer progression . Therefore, targeting of Wnt10B expression or activity may be investigated as a possible strategy for the control of gastric cancer.

摘要

Wnt蛋白家族通过调控细胞命运和模式形成参与胚胎发生，也与人类癌症发生有关。Wnt10B先前已被证明与乳腺癌发展有关。本研究评估了人类胃癌组织标本中Wnt10B表达与这些患者临床病理数据之间的关联。随后研究了Wnt10B表达在调控胃癌细胞增殖和迁移能力中的作用。数据显示，Wnt10B mRNA和蛋白在胃癌组织样本中上调，且上调的Wnt10B mRNA与胃癌转移至淋巴结有关。敲低Wnt10B表达可降低胃癌细胞增殖和迁移，以及细胞增殖标志物Ki67的表达。敲低Wnt10B表达通过上调E-钙黏蛋白和下调N-钙黏蛋白抑制肿瘤细胞上皮-间质转化。此外，Wnt10B敲低还通过下调八聚体结合转录因子4和Nanog表达抑制肿瘤细胞干性。目前的数据表明，Wnt10B表达在胃癌进展中起重要作用。因此，靶向Wnt10B表达或活性可能作为控制胃癌的一种可能策略进行研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/4ecc6ed2f042/ol-13-06-4231-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/a8ec0374ee2f/ol-13-06-4231-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/f6beefd34d02/ol-13-06-4231-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/4ecc6ed2f042/ol-13-06-4231-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/a8ec0374ee2f/ol-13-06-4231-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/f6beefd34d02/ol-13-06-4231-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b27e/5452953/4ecc6ed2f042/ol-13-06-4231-g02.jpg

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