Yu Junxiu, Zheng Wanlei
Department of Gastrointestinal Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, People's Republic of China.
Department of Gastrointestinal Surgery, Liaocheng People's Hospital, 67 Dongchang West Road, Dongchangfu District, Liaocheng, Shandong Province, 252000, People's Republic of China.
J Gastrointest Cancer. 2018 Mar;49(1):57-62. doi: 10.1007/s12029-016-9912-7.
The goal of this study was to create a novel method for screening gastric cancer (GC) based on serum levels of carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4) tumor markers.
Retrospectively, the predictive value for GC was calculated using a logistic analysis on serum levels of CEA, CA19-9, and CA72-4 from 216 GC and 49 benign patients. The predictive value was used to make a recommendation system on whether further GC screening was necessary. Prospectively, 80 GC and 33 benign patients were used to assess the value of this method.
The recommendation system to determine whether additional GC screening was necessary consisted of three grades: grade I, no proposals; grade II, proposals; grade III, strong proposals. Additional screening was suggested when the predictive value was ≤0.700 (grade I), 0.700-0.850 (grade II), and >0.850 (grade III). Of the total 216 GC patients, 20.4, 27.8, and 51.9% were classified as grades I, II, and III, respectively. Of the 49 benign cases, 57.1, 32.7, and 10.2% were classified as grades I, II, and III, respectively. Of the 80 prospective GC patients, 17.3, 28.4, and 54.3% were classified as grades I, II, and III, respectively. Of the 33 prospective benign cases, 54.6, 33.3, and 12.1% were classified as grades I, II, and III, respectively.
The new screening recommendation system based on serum levels of CEA, CA19-9, and CA72-4 is an effective approach for detecting GC.
本研究的目标是创建一种基于癌胚抗原（CEA）、癌抗原19-9（CA19-9）和癌抗原72-4（CA72-4）肿瘤标志物血清水平的新型胃癌（GC）筛查方法。
回顾性地对216例胃癌患者和49例良性疾病患者的CEA、CA19-9和CA72-4血清水平进行逻辑分析，计算其对胃癌的预测价值。该预测价值用于建立一个关于是否需要进一步进行胃癌筛查的推荐系统。前瞻性地选取80例胃癌患者和33例良性疾病患者来评估该方法的价值。
判断是否需要额外进行胃癌筛查的推荐系统分为三个等级：一级，无建议；二级，建议；三级，强烈建议。当预测价值≤0.700（一级）、0.700 - 0.850（二级）和>0.850（三级）时，建议进行额外筛查。在总共216例胃癌患者中，分别有20.4%、27.8%和51.9%被归类为一级、二级和三级。在49例良性病例中，分别有57.1%、32.7%和10.2%被归类为一级、二级和三级。在80例前瞻性胃癌患者中，分别有17.3%、28.4%和54.3%被归类为一级、二级和三级。在33例前瞻性良性病例中，分别有54.6%、33.3%和12.1%被归类为一级、二级和三级。
基于CEA、CA19-9和CA72-4血清水平的新型筛查推荐系统是检测胃癌的有效方法。
