Setthawatcharawanich Suwanna, Sathirapanya Pornchai, Phabphal Kanitpong, Limapichat Kitti
Division of Neurology, Department of Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Clin Neurol Neurosurg. 2011 Dec;113(10):885-8. doi: 10.1016/j.clineuro.2011.07.001. Epub 2011 Jul 30.
To validate and simplify a screening questionnaire for the determination of PD.
The screening questionnaire for PD was developed with the permission of the author. Reliability of the questionnaire was tested. To validate the questionnaire, 40 patients with PD and 93 controls completed the questionnaire. Multiple logistic regression analysis was used to determine the questions independently associated with PD and a risk score was calculated. The predictive performance of the risk score was evaluated via the area under the curve (AUC) of a receiver operating characteristics (ROC) curve.
The questionnaire showed a Cronbach's alpha coefficient of 0.73 with no difference between the initial and follow up scores. The mean content validity was 0.86. Of the 11 questions, 4 were independently associated with PD and were used to calculate the risk score. The scores of these questions were 2 (clumsiness)+4 (tremor)+2 (masked face)+2 (loss of balance while turning). The AUC of a ROC curve for the sum of risk score was 0.95. With a cutoff score of 5 or higher, the sensitivity and specificity were 0.88 and 0.95, respectively.
The screening questionnaire for PD is a reliable and valid instrument. The predictive performance of the simplified questionnaire is as good as the original.
验证并简化用于帕金森病（PD）诊断的筛查问卷。
经作者许可开发了PD筛查问卷。对问卷的信度进行了测试。为验证该问卷，40例PD患者和93名对照完成了问卷。采用多元逻辑回归分析确定与PD独立相关的问题并计算风险评分。通过受试者操作特征（ROC）曲线的曲线下面积（AUC）评估风险评分的预测性能。
问卷的Cronbach's α系数为0.73，初始得分与随访得分无差异。平均内容效度为0.86。11个问题中，4个与PD独立相关并用于计算风险评分。这些问题的得分分别为2（笨拙）+4（震颤）+2（面具脸）+2（转身时失去平衡）。风险评分总和的ROC曲线AUC为0.95。截断分数为5或更高时，灵敏度和特异度分别为0.88和0.95。
PD筛查问卷是一种可靠且有效的工具。简化问卷的预测性能与原问卷一样好。
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