Institute of Legal Medicine, University of Frankfurt/Main, Frankfurt/Main, Germany.
Forensic Sci Int. 2012 Jan 10;214(1-3):e6-8. doi: 10.1016/j.forsciint.2011.06.025. Epub 2011 Jul 30.
As the new drug Spice hit the market in 2006 and was a hot topic in the media, the general issue of legal highs has been brought to the attention of a large number of (young) people. One of these so called legal highs are the seeds of Argyreia nervosa, also known as Hawaiian Baby Woodrose, which contains the psychotropic alkaloid lysergic acid amide (LSA). A study was designed to assess how driving ability is affected by Argyreia nervosa. However, the study could not be continued due to severe adverse effects in 3 of 4 subjects, such as cardiovascular dysregulation in two and a psychosis like state in one subject. All of the participants recovered completely within 9h after ingestion. Despite body normalized doses interindividually highly differing reactions in type and intensity were observed. Furthermore, fluctuating alkaloid contents in seeds and multi-drug intoxications make the use of this legal high far more dangerous than commonly believed.
随着新型毒品 Spice 于 2006 年上市并成为媒体热议的话题，许多（年轻）人开始关注合法兴奋剂的一般问题。所谓的合法兴奋剂之一是含羞草的种子，也称为夏威夷婴儿木薯，它含有精神活性生物碱 LSD 酰胺（LSA）。一项研究旨在评估含羞草种子如何影响驾驶能力。然而，由于 4 名受试者中的 3 名出现严重不良反应，该研究不得不停止，这 3 名受试者中有 2 名出现心血管失调，1 名出现类似精神病的状态。所有参与者在摄入后 9 小时内完全恢复。尽管个体间的剂量正常化，但观察到的反应类型和强度存在很大差异。此外，种子中生物碱含量的波动和多药中毒使得这种合法兴奋剂的使用比人们普遍认为的要危险得多。
