Department of Human Biology, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands.
Cardiovasc Res. 2011 Oct 1;92(1):10-8. doi: 10.1093/cvr/cvr212. Epub 2011 Jul 29.
As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the incidence and prevalence of obesity- and diabetes-related co-morbidities are increasing. In type 2 diabetes ectopic lipid accumulation in the heart has been associated with cardiac dysfunction and apoptosis, a process termed lipotoxicity. Since cardiovascular diseases are the main cause of death in diabetic patients, diagnosis and treatment become increasingly important. Although ischaemic heart disease is a major problem in diabetes, non-ischaemic heart disease (better known as diabetic cardiomyopathy) becomes increasingly important with respect to the impairment of cardiac function and mortality in type 2 diabetes. The underlying aetiology of diabetic cardiomyopathy is incompletely understood but is beginning to be elucidated. Various mechanisms have been proposed that may lead to lipotoxicity. Therefore, this review will focus on the mechanisms of cardiac lipid accumulation and its relation to the development of cardiomyopathy.
随着肥胖症和 2 型糖尿病在西方国家的流行，肥胖症和糖尿病相关合并症的发病率和患病率正在上升。在 2 型糖尿病中，心脏内的异位脂质积累与心脏功能障碍和细胞凋亡有关，这一过程被称为脂毒性。由于心血管疾病是糖尿病患者死亡的主要原因，因此诊断和治疗变得越来越重要。虽然缺血性心脏病是糖尿病的一个主要问题，但非缺血性心脏病（更通俗地称为糖尿病性心肌病）在 2 型糖尿病患者的心脏功能障碍和死亡率方面变得越来越重要。糖尿病性心肌病的潜在病因尚不完全清楚，但正在逐渐阐明。已经提出了各种可能导致脂毒性的机制。因此，本文将重点讨论心脏脂质积累的机制及其与心肌病发展的关系。
