放射性标记脂蛋白以研究和管理疾病。
Radiolabeling lipoproteins to study and manage disease.
作者信息
Pérez-Medina Carlos, Fisher Edward A, Fayad Zahi A, Mulder Willem J M, Teunissen Abraham J P
机构信息
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Department of Medicine (Cardiology), New York University Grossman School of Medicine, New York, NY, USA.
出版信息
Eur J Nucl Med Mol Imaging. 2025 Apr 28. doi: 10.1007/s00259-025-07281-4.
PURPOSE
Lipoproteins are endogenous nanoparticles with essential roles in lipid transport and inflammation. Lipoproteins are also valuable in diagnosing and treating disease. For instance, certain lipoproteins are overexpressed in patients with atherosclerotic cardiovascular disease, and reconstituted lipoproteins have been extensively used for drug delivery. Radiolabeling has proven an especially powerful approach for studying and therapeutically exploiting lipoproteins. This review details how radiochemistry and nuclear imaging can facilitate the study of lipoproteins in health and disease. Among other topics, we discuss approaches for radiolabeling lipoproteins and detail how these have helped advance our understanding of lipoprotein biology and the diagnosis and treatment of diseases, including atherosclerosis, cancer, and hypercholesteremia.
METHODS
We performed an extensive literature search on all peer-reviewed studies involving radiolabeled lipoproteins and selected representative examples to provide a high-level overview of the most important discoveries and technological advancements.
RESULTS
More than 200 peer-reviewed papers involved radiolabeled lipoproteins, spanning mechanistic, diagnostic, and therapeutic studies across a wide range of diseases.
CONCLUSION
Radiolabeling has been critical in advancing our understanding of lipoprotein biology and leveraging these nanomaterials for diagnosing and treating disease.
目的
脂蛋白是内源性纳米颗粒，在脂质运输和炎症中起重要作用。脂蛋白在疾病的诊断和治疗中也具有重要价值。例如，某些脂蛋白在动脉粥样硬化性心血管疾病患者中过度表达，重组脂蛋白已广泛用于药物递送。放射性标记已被证明是研究和治疗性利用脂蛋白的一种特别有效的方法。本综述详细介绍了放射化学和核成像如何促进对健康和疾病状态下脂蛋白的研究。除其他主题外，我们讨论了脂蛋白放射性标记的方法，并详细说明了这些方法如何有助于增进我们对脂蛋白生物学以及包括动脉粥样硬化、癌症和高胆固醇血症在内的疾病的诊断和治疗的理解。
方法
我们对所有涉及放射性标记脂蛋白的同行评审研究进行了广泛的文献检索，并选择了具有代表性的例子，以提供对最重要发现和技术进步的高层次概述。
结果
200多篇同行评审论文涉及放射性标记脂蛋白，涵盖了广泛疾病的机制、诊断和治疗研究。
结论
放射性标记对于增进我们对脂蛋白生物学的理解以及利用这些纳米材料进行疾病诊断和治疗至关重要。
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