Chen Congfei, Xu Longfei, Wang Kun, Wang Tianhui
Tianjin Key Laboratory of Exercise Physiology & Sports Medicine, Tianjin University of Sport, Tianjin, 301617, China.
Military Medical Sciences Academy, 1 Dali Road, Heping District, Tianjin, 300050, P. R. China.
J Cardiovasc Transl Res. 2025 Jun 4. doi: 10.1007/s12265-025-10630-1.
Diabetic myocardial disorder is characterized by myocardial dysfunction in diabetes mellitus patients, independent of other heart disease causes like coronary artery disease or hypertension. This condition threatens the well-being of patients. At the cellular and molecular levels, disruptions in cardiomyocyte metabolism, abnormal calcium signaling, and increased reactive oxygen species production, among others, interconnect to create a complex pathological network that worsens myocardial cell damage and leads to cardiac dysfunction symptoms. The limited effectiveness of current pharmacological treatments has increased the appeal of non-pharmacological therapies, especially exercise therapy. Exercise is anticipated to ameliorate diabetic myocardial disease through pleiotropic beneficial effects. The fundamental mechanisms behind these benefits remain unclear; further investigation of these mechanisms will aid in developing targeted therapies. This paper aims to explore how exercise affects myocardial metabolism, antioxidant capacity, fibrosis, and microangiopathy while providing an overview of key mechanisms and recent breakthroughs to encourage ongoing research in this area.
糖尿病性心肌病变的特征是糖尿病患者出现心肌功能障碍，且独立于冠状动脉疾病或高血压等其他心脏病病因。这种情况威胁着患者的健康。在细胞和分子水平上，心肌细胞代谢紊乱、钙信号异常以及活性氧生成增加等相互关联，形成一个复杂的病理网络，加剧心肌细胞损伤并导致心脏功能障碍症状。当前药物治疗效果有限，这增加了非药物疗法的吸引力，尤其是运动疗法。预计运动可通过多方面的有益作用改善糖尿病性心肌病。这些益处背后的基本机制尚不清楚；对这些机制的进一步研究将有助于开发靶向治疗方法。本文旨在探讨运动如何影响心肌代谢、抗氧化能力、纤维化和微血管病变，同时概述关键机制和近期突破，以鼓励该领域的持续研究。
