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Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations.

作者信息

Brune Kay, Hinz Burkhard

出版信息

Ann Rheum Dis. 2011 Sep;70(9):1521-2. doi: 10.1136/annrheumdis-2011-200242.

DOI:10.1136/annrheumdis-2011-200242
PMID:21804098
Abstract
摘要

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1
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations.对乙酰氨基酚、布洛芬或两者联合用药治疗膝关节疼痛：一项出色的新随机临床试验解答了旧问题并提出了新的治疗建议。
Ann Rheum Dis. 2011 Sep;70(9):1521-2. doi: 10.1136/annrheumdis-2011-200242.
2
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.一项关于布洛芬、对乙酰氨基酚或布洛芬/对乙酰氨基酚复方片剂在社区来源的膝关节疼痛人群中的随机对照试验。
Ann Rheum Dis. 2011 Sep;70(9):1534-41. doi: 10.1136/ard.2011.154047.
3
Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth.布洛芬和/或对乙酰氨基酚用于拔除下颌智齿后的止痛。
Cochrane Database Syst Rev. 2013 Dec 12;2013(12):CD004624. doi: 10.1002/14651858.CD004624.pub2.
4
Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries.对患有四肢损伤的儿童而言，扑热息痛/可待因可能具有与布洛芬等效的镇痛作用。
Arch Dis Child Educ Pract Ed. 2010 Oct;95(5):167. doi: 10.1136/adc.2010.192435. Epub 2010 Jun 28.
5
Metamizole vs. ibuprofen at home after day case surgery: A double-blind randomised controlled noninferiority trial.氨酚待因与布洛芬用于日间手术后家庭治疗的比较：一项双盲随机对照非劣效性试验。
Eur J Anaesthesiol. 2019 May;36(5):351-359. doi: 10.1097/EJA.0000000000000972.
6
[Ibuprofen/paracetamol combination therapy is more effective than monotherapy in knee pain, but increases bleeding risk].布洛芬/对乙酰氨基酚联合疗法在缓解膝关节疼痛方面比单一疗法更有效，但会增加出血风险。
Praxis (Bern 1994). 2012 Mar 14;101(6):427-8. doi: 10.1024/1661-8157/a000871.
7
Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial.帕瑞昔布（醋氨酚）和布洛芬联合与单独用药对全髋关节置换术后 24 小时内患者自控吗啡消耗量的影响：PANSAID 随机临床试验。
JAMA. 2019 Feb 12;321(6):562-571. doi: 10.1001/jama.2018.22039.
8
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain.单剂量口服布洛芬加对乙酰氨基酚用于术后急性疼痛
Cochrane Database Syst Rev. 2013 Jun 24;2013(6):CD010210. doi: 10.1002/14651858.CD010210.pub2.
9
PANSAID-PAracetamol and NSAID in combination: detailed statistical analysis plan for a randomised, blinded, parallel, four-group multicentre clinical trial.帕纳昔布——对乙酰氨基酚与非甾体抗炎药联合使用：一项随机、双盲、平行、四组多中心临床试验的详细统计分析计划
Trials. 2017 Oct 10;18(1):465. doi: 10.1186/s13063-017-2203-1.
10
Efficacy of Codeine When Added to Paracetamol (Acetaminophen) and Ibuprofen for Relief of Postoperative Pain After Surgical Removal of Impacted Third Molars: A Double-Blinded Randomized Control Trial.可待因添加到对乙酰氨基酚和布洛芬中用于缓解阻生第三磨牙拔除术后疼痛的疗效：一项双盲随机对照试验
J Oral Maxillofac Surg. 2017 Oct;75(10):2063-2069. doi: 10.1016/j.joms.2017.04.045. Epub 2017 May 15.

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Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing.对乙酰氨基酚在伤害性感受处理临床前模型中的全身和神经轴效应的系统评价
J Pain Res. 2021 Nov 12;14:3521-3552. doi: 10.2147/JPR.S308028. eCollection 2021.
2
[Perioperative analgesia with nonopioid analgesics : Joint interdisciplinary consensus-based recommendations of the German Pain Society, the German Society of Anaesthesiology and Intensive Care Medicine and the German Society of Surgery].[非阿片类镇痛药的围手术期镇痛：德国疼痛学会、德国麻醉与重症医学学会和德国外科学会基于跨学科共识的联合推荐]
Anaesthesist. 2021 Aug;70(8):689-705. doi: 10.1007/s00101-021-01010-w. Epub 2021 Jul 19.
3
[Perioperative analgesia with nonopioid analgesics : Joint interdisciplinary consensus-based recommendations of the German Pain Society, the German Society of Anaesthesiology and Intensive Care Medicine and the German Society of Surgery].
[非阿片类镇痛药的围手术期镇痛：德国疼痛学会、德国麻醉与重症医学学会和德国外科学会基于跨学科共识的联合推荐]
Schmerz. 2021 Aug;35(4):265-281. doi: 10.1007/s00482-021-00566-1.
4
[Perioperative analgesia with nonopioid analgesics : Joint interdisciplinary consensus-based recommendations of the German Pain Society, the German Society of Anaesthesiology and Intensive Care Medicine and the German Society of Surgery].[非阿片类镇痛药的围手术期镇痛：德国疼痛学会、德国麻醉与重症医学学会和德国外科学会基于跨学科共识的联合推荐]
Chirurg. 2021 Jul;92(7):647-663. doi: 10.1007/s00104-021-01421-w. Epub 2021 May 26.
5
A Study of Method Development, Validation, and Forced Degradation for Simultaneous Quantification of Paracetamol and Ibuprofen in Pharmaceutical Dosage Form by RP-HPLC Method.采用反相高效液相色谱法同时定量测定药物剂型中对乙酰氨基酚和布洛芬的方法开发、验证及强制降解研究
Anal Chem Insights. 2014 Nov 18;9:75-81. doi: 10.4137/ACI.S18651. eCollection 2014.
6
Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis.氨基葡萄糖和硫酸软骨素联合使用，每日一次或三次，可为膝骨关节炎提供具有临床意义的镇痛效果。
Clin Rheumatol. 2015 Aug;34(8):1455-62. doi: 10.1007/s10067-014-2757-1. Epub 2014 Aug 3.
7
UV spectrophotometric simultaneous determination of paracetamol and ibuprofen in combined tablets by derivative and wavelet transforms.紫外分光光度法结合导数和小波变换同时测定复方片剂中对乙酰氨基酚和布洛芬的含量
ScientificWorldJournal. 2014;2014:313609. doi: 10.1155/2014/313609. Epub 2014 Feb 19.