雌激素受体多态性与晚年抑郁症。
Oestrogen receptor polymorphisms and late-life depression.
机构信息
Inserm U1061, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier Cedex 5, France.
出版信息
Br J Psychiatry. 2011 Aug;199(2):126-31. doi: 10.1192/bjp.bp.111.091751.
Abstract
BACKGROUND
Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown.
AIMS
To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.
METHOD
Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression.
RESULTS
In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk.
CONCLUSIONS
Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
摘要
背景
有证据表明雌激素在抑郁症中起作用，但雌激素受体多态性的参与仍不清楚。
目的
确定雌激素受体多态性与老年抑郁症的关系，以及激素治疗的修饰作用。
方法
使用DSM-IV 标准和流行病学研究中心抑郁量表，通过 Mini-国际神经精神病学访谈评估抑郁。使用多元逻辑回归分析，在 6017 名社区居住的老年人中，研究了雌激素受体α和β（ER-α 和 ER-β）多态性与严重抑郁症之间的关系。
结果
在女性中，ER-α rs2234693 和 rs9340799 多态性与晚年抑郁症的风险显著相关。ER-β rs1256049 的 A 等位基因增加了患抑郁症的风险，但仅适用于非当前使用激素治疗的患者。在男性中，只有 ER-β rs4986938 多态性与抑郁症风险呈弱相关。
结论
雌激素受体多态性仅与女性严重的晚年抑郁症风险相关。
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