慢性肾脏病患者的动脉僵硬度。
Arterial stiffness in patients with chronic kidney disease.
机构信息
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Am J Med Sci. 2012 Feb;343(2):109-113. doi: 10.1097/MAJ.0b013e318223e814.
INTRODUCTION
Brachial-ankle pulse wave velocity (baPWV) was a marker of arterial stiffness, and increased baPWV was associated with renal function progression in patients with chronic kidney disease (CKD). However, there was no study to evaluate the longitudinal change of baPWV in patients with CKD. The aims of this study were to assess whether there was a longitudinal change in baPWV and to find out the determinants of this change in patients with CKD.
METHODS
This study enrolled 52 patients with CKD stages 3 to 5 from outpatient Department of Internal Medicine. The values of baPWV were measured by an ankle-brachial index-form device at baseline and at 2-year follow-up. Changes of parameters (Δ) were used to evaluate the relationship between biological markers, blood pressures, medications and baPWV.
RESULTS
The values of baPWV decreased during the 2-year follow-up (2108.4 ± 893.9 and 1897.1 ± 472.4; P = 0.016). There were also significant reductions in systolic and diastolic blood pressures during the 2-year follow-up, and Δsystolic blood pressure and baseline baPWV were the major determinants of ΔbaPWV.
CONCLUSIONS
The present longitudinal study showed that the values of baPWV decreased during the 2-year follow-up, and the major determinants of ΔbaPWV were Δsystolic blood pressure and baseline baPWV in patients with CKD. Good control of systolic blood pressure may be associated with the regression of baPWV in patients with CKD.
简介
肱踝脉搏波速度（baPWV）是动脉僵硬度的标志物，在慢性肾脏病（CKD）患者中，baPWV 升高与肾功能进展相关。然而，目前尚无研究评估 CKD 患者 baPWV 的纵向变化。本研究旨在评估 CKD 患者的 baPWV 是否存在纵向变化，并找出该变化的决定因素。
方法
本研究纳入了来自内科门诊的 52 名 CKD 3-5 期患者。基线和 2 年随访时，使用踝臂指数仪设备测量 baPWV 值。使用参数变化（Δ）来评估生物标志物、血压、药物和 baPWV 之间的关系。
结果
在 2 年随访期间，baPWV 值下降（2108.4 ± 893.9 和 1897.1 ± 472.4；P = 0.016）。2 年随访期间，收缩压和舒张压也显著降低，Δ收缩压和基线 baPWV 是ΔbaPWV 的主要决定因素。
结论
本纵向研究表明，在 2 年随访期间，baPWV 值下降，CKD 患者的ΔbaPWV 的主要决定因素是Δ收缩压和基线 baPWV。收缩压的良好控制可能与 CKD 患者 baPWV 的逆转有关。
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