Jahan I, Hanif M, Ali M A, Waliullah S M, Mia A H
Dhaka Shishu Hospital, Dhaka, Bangladesh.
Mymensingh Med J. 2011 Jul;20(3):484-9.
This prospective case control study was carried out in Renal and Dialysis Unit of Dhaka Shishu Hospital, Bangladesh from January 2004 to December 2004 to determine serum IgE level in frequent relapse Idiopathic nephrotic syndrome and to evaluate any role of IgE in the rate of relapse. Thirty cases of frequent relapse (FR) Idiopathic nephrotic syndrome (INS) were considered as cases and thirty cases of infrequent relapse nephrotic syndrome (IRNS) were considered as control. Serum IgE level was measured in all patients at the time of relapse and again four weeks after steroid treatment when patient was in remission. The test statistics used to analyses the data were descriptive statistics, Chi-square probability test, Student's "t"-Test, Mann Whitney test and Wilcoxon Signed Rank test. Majority of the patients' age in both the groups was between 2-6 years. The male female ratio in FR group was 2:1, while that in IR group was 3:2. Forty percent of the frequent relapsers and 30% of infrequent relapsers were found to possess the history of atopy. However, the difference between the two groups was not statistically significant (p>0.05). The mean serum albumin in FR was observed to be significantly lower (13.73±0.59 gm/L) than that in IR (15.73±0.67 gm/L) (p<0.05). Mean serum IgE at the time of relapse in FR (1791±95 IU/mL) was found to be more than 3 times higher than that in IR (560±50 IU/mL) (p<0.001). Serum IgE level at the time of remission has decreased to almost normal in IR group (204±21 IU/mL) but it was still found 5 times higher in FR group (1086±79 IU/mL) (p<0.001). Serum IgE level is high in both FR and IR groups of nephrotic syndrome at the time of relapse. It reverts back to normal in IRNS but persistently and significantly high in FR group in both relapse and remission. Level of the serum IgE can be used as a predictor of FRNS.
本前瞻性病例对照研究于2004年1月至2004年12月在孟加拉国达卡儿童医院的肾脏与透析科开展，旨在测定频繁复发的特发性肾病综合征患者的血清IgE水平，并评估IgE在复发率中的作用。30例频繁复发（FR）的特发性肾病综合征（INS）患者被视为病例组，30例非频繁复发的肾病综合征（IRNS）患者被视为对照组。在所有患者复发时及类固醇治疗四周后病情缓解时均测量血清IgE水平。用于分析数据的检验统计量包括描述性统计、卡方概率检验、学生“t”检验、曼-惠特尼检验和威尔科克森符号秩检验。两组中大多数患者年龄在2至6岁之间。FR组男女比例为2:1，而IR组为3:2。发现40%的频繁复发患者和30%的非频繁复发患者有特应性病史。然而，两组之间的差异无统计学意义（p>0.05）。观察到FR组的平均血清白蛋白（13.73±0.59 g/L）显著低于IR组（15.73±0.67 g/L）（p<0.05）。FR组复发时的平均血清IgE（1791±95 IU/mL）比IR组（560±50 IU/mL）高出3倍多（p<0.001）。IR组缓解时的血清IgE水平已降至几乎正常（204±21 IU/mL），但FR组仍高出5倍（1086±79 IU/mL）（p<0.001）。肾病综合征的FR组和IR组在复发时血清IgE水平均较高。在IRNS中其恢复正常，但在FR组中复发和缓解时均持续且显著升高。血清IgE水平可作为FRNS的预测指标。
