10p12.31 附近的 MLLT10 附近常见的变异会影响脑膜瘤的风险。
Common variation at 10p12.31 near MLLT10 influences meningioma risk.
机构信息
Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
出版信息
Nat Genet. 2011 Jul 31;43(9):825-7. doi: 10.1038/ng.879.
To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
为了确定脑膜瘤的易感基因座，我们对 859 名患者（病例）和 704 名对照进行了全基因组关联研究，并在两个独立的样本集中进行了验证，共包括 774 名患者和 1764 名对照。我们在 10p12.31 上发现了一个新的脑膜瘤易感基因座（MLLT10，rs11012732，比值比=1.46，P（合并）=1.88×10(-14)）。这一发现增进了我们对脑膜瘤发病机制的遗传基础的理解。
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