10p12.31 附近的 MLLT10 附近常见的变异会影响脑膜瘤的风险。
Common variation at 10p12.31 near MLLT10 influences meningioma risk.
机构信息
Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
出版信息
Nat Genet. 2011 Jul 31;43(9):825-7. doi: 10.1038/ng.879.
Abstract
To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
摘要
为了确定脑膜瘤的易感基因座，我们对 859 名患者（病例）和 704 名对照进行了全基因组关联研究，并在两个独立的样本集中进行了验证，共包括 774 名患者和 1764 名对照。我们在 10p12.31 上发现了一个新的脑膜瘤易感基因座（MLLT10，rs11012732，比值比=1.46，P（合并）=1.88×10(-14)）。这一发现增进了我们对脑膜瘤发病机制的遗传基础的理解。
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本文引用的文献
1
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2
Epidemiology and etiology of meningioma.
J Neurooncol. 2010 Sep;99(3):307-14. doi: 10.1007/s11060-010-0386-3. Epub 2010 Sep 7.
3
Pathological classification and molecular genetics of meningiomas.
J Neurooncol. 2010 Sep;99(3):379-91. doi: 10.1007/s11060-010-0342-2. Epub 2010 Sep 1.
4
Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway.
Mol Cell Biol. 2009 Nov;29(21):5923-40. doi: 10.1128/MCB.00332-09. Epub 2009 Aug 24.
5
National study of colorectal cancer genetics.
Br J Cancer. 2007 Nov 5;97(9):1305-9. doi: 10.1038/sj.bjc.6603997. Epub 2007 Sep 25.
6
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Am J Hum Genet. 2007 Sep;81(3):559-75. doi: 10.1086/519795. Epub 2007 Jul 25.
7
The INTERPHONE study: design, epidemiological methods, and description of the study population.
Eur J Epidemiol. 2007;22(9):647-64. doi: 10.1007/s10654-007-9152-z. Epub 2007 Jul 18.
8
Molecular genetics of meningiomas: from basic research to potential clinical applications.
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9
Relative impact of nucleotide and copy number variation on gene expression phenotypes.
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10
PReMod: a database of genome-wide mammalian cis-regulatory module predictions.
Nucleic Acids Res. 2007 Jan;35(Database issue):D122-6. doi: 10.1093/nar/gkl879. Epub 2006 Dec 5.
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