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合并对制药研发的影响。

The impact of mergers on pharmaceutical R&D.

机构信息

Puretech Ventures, Boston, Massachusetts 02116, USA.

出版信息

Nat Rev Drug Discov. 2011 Aug 1;10(8):559-60. doi: 10.1038/nrd3514.

DOI:10.1038/nrd3514
PMID:21804580
Abstract

Mergers and acquisitions in the pharmaceutical industry have substantially reduced the number of major companies over the past 15 years. The short-term business rationale for this extensive consolidation might have been reasonable, but at what cost to research and development productivity?

摘要

在过去的 15 年中,制药行业的并购大大减少了主要公司的数量。这种广泛整合的短期商业理由可能是合理的,但对研发生产力造成了什么代价?

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本文引用的文献

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How to improve R&D productivity: the pharmaceutical industry's grand challenge.如何提高研发生产力:制药行业的重大挑战。
Nat Rev Drug Discov. 2010 Mar;9(3):203-14. doi: 10.1038/nrd3078. Epub 2010 Feb 19.
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Lessons from 60 years of pharmaceutical innovation.60年药物创新的经验教训。
Nat Rev Drug Discov. 2009 Dec;8(12):959-68. doi: 10.1038/nrd2961.
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Rebuilding the R&D engine in big pharma.重塑大型制药公司的研发引擎。
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Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact.对医药公私合作伙伴关系未来的反思:从投入到影响。
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Drug Dev Res. 2017 Feb;78(1):3-23. doi: 10.1002/ddr.21369. Epub 2016 Oct 21.
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Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files.基于平板的多样性子集筛选第二代:用于高通量筛选大型化合物文件的改进范式。
Mol Divers. 2016 Nov;20(4):789-803. doi: 10.1007/s11030-016-9692-9. Epub 2016 Sep 8.
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Changing R&D models in research-based pharmaceutical companies.研发型制药公司研发模式的转变。
J Transl Med. 2016 Apr 27;14(1):105. doi: 10.1186/s12967-016-0838-4.
8
Association Between the Number of Suppliers for Critical Antineoplastics and Drug Shortages: Implications for Future Drug Shortages and Treatment.关键抗肿瘤药物供应商数量与药品短缺之间的关联:对未来药品短缺及治疗的影响
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Bridging academic science and clinical research in the search for novel targeted anti-cancer agents.在寻找新型靶向抗癌药物的过程中搭建学术科学与临床研究之间的桥梁。
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