García-Berrocoso Teresa, Fernández-Cadenas Israel, Delgado Pilar, Rosell Anna, Montaner Joan
Neurovascular Research Laboratory, Institut de Recerca Vall d'Hebron and Neurovascular Unit Neurology Department. Universitat Autònoma de Barcelona. Medicine Department. Hospital Vall d'Hebron. Barcelona, Spain.
Curr Cardiol Rev. 2010 Aug;6(3):194-201. doi: 10.2174/157340310791658767.
One promising field in neurovascular diseases investigation is the use of biomarkers to guide stroke etiology diagnosis and classification. Since treatment differs among etiologic subtypes and nowadays many patients receive a diagnosis of undetermined stroke, biomarkers might become an important additional diagnostic tool. In this review we update current knowledge about biomarkers related with cardioembolic stroke etiology (such as BNP and D-dimer proteins, or PITX2 and ZFHX3 genes), that in the future, might allow rapidly guiding other diagnostic tests and accelerating the onset of an optimal secondary prevention.
神经血管疾病研究中一个很有前景的领域是利用生物标志物来指导中风病因诊断和分类。由于不同病因亚型的治疗方法不同,且如今许多患者被诊断为不明原因中风,生物标志物可能会成为一种重要的辅助诊断工具。在本综述中,我们更新了有关与心源性栓塞性中风病因相关的生物标志物(如脑钠肽和D-二聚体蛋白,或PITX2和ZFHX3基因)的现有知识,这些生物标志物未来可能有助于快速指导其他诊断测试,并加速最佳二级预防的开始。