减肥能治愈2型糖尿病？事实还是幻想。
Weight Loss as a Cure for Type 2 Diabetes? Fact or Fantasy.
作者信息
Kashyap Sangeeta R, Louis Emily S, Kirwan John P
机构信息
Endocrinology and Metabolism Institute, Cleveland Clinic OH 44195.
出版信息
Expert Rev Endocrinol Metab. 2011 Jul 1;6(4):557-561. doi: 10.1586/eem.11.42.
Abstract
Although individuals with obesity and type 2 diabetes are insulin resistant, pancreatic beta cell failure is the core defect that distinguishes individuals who eventually develop diabetes. This process is known to occur well before the onset of hyperglycemia. Although clinical trial data support the effectiveness of intensive lifestyle modification in delaying the onset of diabetes in obese subjects, less is known about the effects of and mechanisms underlying bariatric surgery, particularly gastric bypass surgery, on diabetes. The paper under evaluation clarifies the role of both lifestyle intervention and gastric bypass surgery on pancreatic beta cell function and raises questions regarding the role of weight loss versus incretin related mechanisms on recovery of beta cell failure.
摘要
虽然肥胖和2型糖尿病患者存在胰岛素抵抗，但胰腺β细胞功能衰竭是区分最终发展为糖尿病的个体的核心缺陷。已知这个过程在高血糖发作之前就已发生。尽管临床试验数据支持强化生活方式改变在延缓肥胖受试者糖尿病发作方面的有效性，但关于减肥手术，尤其是胃旁路手术对糖尿病的影响及潜在机制，我们了解得较少。正在评估的这篇论文阐明了生活方式干预和胃旁路手术对胰腺β细胞功能的作用，并提出了关于体重减轻与肠促胰岛素相关机制在β细胞功能衰竭恢复中的作用的问题。
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本文引用的文献
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