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减重手术后 1 年 2 型糖尿病缓解的预测因素:手术技术的影响。

Predictive factors of type 2 diabetes remission 1 year after bariatric surgery: impact of surgical techniques.

机构信息

Department of Digestive Surgery, Hospices Civils de Lyon, Hôpital Edouard Herriot, 5, place d'Arsonval, 69008, Lyon, France.

出版信息

Obes Surg. 2013 Jun;23(6):770-5. doi: 10.1007/s11695-013-0868-4.

DOI:10.1007/s11695-013-0868-4
PMID:23355293
Abstract

Type 2 diabetes (T2D) remission after bariatric procedures has been highlighted in many retrospective and some recent prospective studies. However, in the most recent prospective study, more than 50 % of patients did not reach T2D remission at 1 year. Our aim was to identify baseline positive predictors for T2D remission at 1 year after bariatric surgery and to build a preoperative predictive score. We analysed the data concerning 161 obese operated on between June 2007 and December 2010. Among them, 46 were diabetic and were included in the study-11 laparoscopic adjustable gastric banding (LAGB), 26 Roux-en-Y gastric bypass (RYGB) and 9 sleeve gastrectomy (SG). We compared anthropometric and metabolic features during 1 year of follow-up. A receiver operating characteristic analysis was performed to predict T2D remission. RYGB and SG were similarly efficient for body weight loss and more efficient than LAGB; 62.8 % of patients presented with T2DM remission at 1 year, with no significant difference according to the surgical procedure. A 1-year body mass index (BMI) <35 kg m(-2) was predictive of T2DM remission whatever the procedure. The preoperative predictive factors of diabetes remission were baseline BMI ≤50 kg m(-2), duration of type 2 diabetes ≤4 years, glycated haemoglobin ≤7.1 %, fasting glucose <1.14 g/l and absence of insulin therapy. A short duration of diabetes and good preoperative glycaemic control increase the rate of T2DM remission 1 year after surgery. Preoperative metabolic data could be of greater importance than the choice of bariatric procedure.

摘要

2 型糖尿病(T2D)在减重手术后的缓解已在许多回顾性和一些近期前瞻性研究中得到强调。然而,在最近的一项前瞻性研究中,超过 50%的患者在 1 年内未达到 T2D 缓解。我们的目的是确定减重手术后 1 年内 T2D 缓解的基线阳性预测因素,并建立术前预测评分。我们分析了 2007 年 6 月至 2010 年 12 月期间接受手术的 161 例肥胖患者的数据。其中,46 例为糖尿病患者,纳入本研究-11 例行腹腔镜可调胃束带术(LAGB),26 例行 Roux-en-Y 胃旁路术(RYGB),9 例行袖状胃切除术(SG)。我们比较了随访 1 年内的人体测量和代谢特征。进行了接受者操作特征分析以预测 T2D 缓解。RYGB 和 SG 在体重减轻方面同样有效,且比 LAGB 更有效;62.8%的患者在 1 年内出现 T2DM 缓解,手术方式无显著差异。1 年内 BMI<35kg/m2 是预测无论手术方式都能缓解 T2DM 的因素。糖尿病缓解的术前预测因素为基线 BMI≤50kg/m2、2 型糖尿病病程≤4 年、糖化血红蛋白≤7.1%、空腹血糖<1.14g/l 和无胰岛素治疗。糖尿病病程较短和术前良好的血糖控制可提高术后 1 年内 T2DM 缓解率。术前代谢数据可能比选择减重手术更为重要。

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Long-term effects of sleeve gastrectomy and Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus in morbidly obese subjects.袖状胃切除术和 Roux-en-Y 胃旁路手术对病态肥胖患者 2 型糖尿病的长期影响。
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Precision Medicine in Bariatric Procedures.减重手术中的精准医学。
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