University of Cambridge, Cavendish Laboratory, Cambridge, CB3 0HE, United Kingdom.
Lab Chip. 2011 Oct 7;11(19):3365-8. doi: 10.1039/c1lc20399a. Epub 2011 Jul 29.
A novel and simple approach for the realization of polymer sub-micrometre channels is introduced by exploiting replica molding of Pt wires deposited by focused ion beam. We fabricate arrays of parallel channels with typical dimensions down to 600 nm and with variable height. We characterize the pressure-driven transport of polymer colloids through the channels in terms of the translocation frequency, amplitude and duration by implementing a laser scattering detection technique. We propose a prototype application of the presented platform such as the in situ sizing and sensing of populations of particles with different dimensions down to 50 nm.
本文采用聚焦离子束沉积 Pt 丝复制模的方法，提出了一种实现聚合物亚微米通道的新颖而简单的方法。我们制作了典型尺寸低至 600nm 且高度可变的平行通道阵列。通过实施激光散射检测技术，我们以易位频率、振幅和持续时间为指标，对聚合物胶体在通道中的压力驱动传输进行了表征。我们提出了该平台的一个原型应用，例如对不同尺寸（低至 50nm）的粒子群体进行原位尺寸测量和传感。
