7-氯喹啉-4-基芳基腙衍生物：合成与抗真菌活性
7-chloroquinolin-4-yl arylhydrazone derivatives: synthesis and antifungal activity.
作者信息
Duval Auri R, Carvalho Pedro H, Soares Maieli C, Gouvêa Daniela P, Siqueira Geonir M, Lund Rafael G, Cunico Wilson
机构信息
NuQuiA – Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, Brazil.
出版信息
ScientificWorldJournal. 2011 Jul 28;11:1489-95. doi: 10.1100/tsw.2011.141.
Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.
已对15种7-氯-4-芳基腙喹啉进行了评估，考察它们对8种口腔真菌的体外抗真菌活性，这8种真菌分别是：白色念珠菌、近平滑念珠菌、解脂念珠菌、热带念珠菌、法塔念珠菌、光滑念珠菌、粘红酵母和胶红酵母。几种化合物表现出的最低抑菌浓度（MIC）和最低杀菌浓度（MFC）活性与一线药物氟康唑相当。这些结果可被视为合理设计新型抗真菌药物的重要起点。
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