Department of Urology, Medical Faculty, Dicle University, Diyarbakir, Turkey.
Int Urol Nephrol. 2012 Apr;44(2):401-8. doi: 10.1007/s11255-011-0038-3. Epub 2011 Jul 30.
Aim of this study is to evaluate the effects of micronised purified flavonoid fraction (Daflon(®)) on pain, semen analysis and color Doppler parameters in patients with painful varicocele.
Forty varicocele patients whom have normal sperm concentration (>20 million/ml) were involved in the study. The patients were divided into two groups such as Daflon (n = 20) and placebo (n = 20) group. Pain score, semen analyses and Doppler sonography were performed in all patients before and after the treatment.
In the first group, mean pain scores at 1, 3, 6 and 12 months were 1.80 ± 1.32, 1.15 ± 0.93, 1.05 ± 0.95 and 0.95 ± 0.89, respectively, all were significantly lower (P < 0.001 for each) than baseline (5.25 ± 1.07). While semen volume, total sperm count, sperm concentration and morphology were not changed significantly, the motility of sperm increased significantly (P = 0.015) due to decrease in grade 1 sperms at the 6th month in the first group. Reflux time of left spermatic vein during the Valsalva maneuver decreased significantly (P < 0.001).
Results of this study suggest the safety and efficacy of Daflon in the treatment of varicocele-associated pain. However, these results of the present study must be confirmed by randomized placebo-controlled studies by using different drug doses and durations before making any recommendation for the use of Daflon.
本研究旨在评估微粒化纯化黄酮类混合物（达肝素钠）对精索静脉曲张患者疼痛、精液分析和彩色多普勒参数的影响。
本研究纳入了 40 例精子浓度正常（>2000 万/ml）的精索静脉曲张患者。将患者分为达肝素钠组（n = 20）和安慰剂组（n = 20）。所有患者在治疗前后均进行疼痛评分、精液分析和多普勒超声检查。
在第一组中，治疗后 1、3、6 和 12 个月的平均疼痛评分分别为 1.80 ± 1.32、1.15 ± 0.93、1.05 ± 0.95 和 0.95 ± 0.89，均显著低于基线水平（P < 0.001 各时间点）。虽然精液量、总精子数、精子浓度和形态无明显变化，但精子活力在第 6 个月因 1 级精子数量减少而显著增加（P = 0.015）。左侧精索静脉在valsalva 动作期间的反流时间显著减少（P < 0.001）。
本研究结果表明达肝素钠治疗精索静脉曲张相关疼痛是安全有效的。然而，在推荐使用达肝素钠之前，必须通过使用不同的药物剂量和持续时间进行随机安慰剂对照研究来证实本研究的结果。
